Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proton pump inhibitors (PPIs) are widely used medicines worldwide. However, a rare etiology of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) related to PPI was recently reported. Therefore, the putative role of PPIs in SIADH cannot be underestimated. A 78-year-old Japanese woman was admitted to our hospital for treatment of left Bell's palsy. On admission, the patient was oriented with normal laboratory data, including a serum Na level of 135 mEq/L. Oral glucocorticoids and a proton pump inhibitor were initiated in combination with oral valaciclovir. Six days later, the patient's consciousness became impaired. Laboratory data showed a serum Na level of 103 mEq/L, a urine Na level of 64.8 mEq/L, a urine K level of 43.6 mEq/L, and a urine osmolality of 450 mOsm/kg H2O. The patient met the criteria for SIADH. The initial treatment included water restriction and 3% hypertonic saline administration. The cessation of PPI significantly improved the urine diluting capacity and concomitantly increased serum Na, which indicated that the use of PPI had been responsible for the etiology of SIADH. The present case illustrates that physicians need to be aware of the uncommon adverse effects of PPI, such as SIADH.
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PMID:Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Very Short-term Use of Proton Pump Inhibitor. 3275 47

The uncommon association between the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and localized Herpes-Zoster infection has been reported in only 16 cases in the literature. We present a case of a patient with Herpes-Zoster Ophthalmicus associated with Bell's Palsy who developed new-onset hyponatremia with criteria for SIADH. The patient was euvolemic and his laboratory results showed a concentration of serum sodium of 127 mmol/L, a serum osmolality of 266,9 mOsm/kg, a urinary osmolality of 259 mOsm/kg and a urine sodium concentration of 67,99 mmol/L. After excluding other possible causes, we concluded the diagnosis of SIADH secondary to the viral infection. He was treated with intravenous acyclovir for seven days, systemic corticoids and topical eye treatments. The vesicular lesions resolved with treatment and the serum sodium concentration progressively returned to normal levels, with a value of 136 mmol/L at discharge. Some complications further developed included herpetic keratitis and a corneal ulcer of the right eye. SIADH secondary to localized Herpes-Zoster is a rare entity, but it is important to be recognized by clinicians. This clinical case reinforces the hypothesis of the existence of a relationship between these two diseases, being the only case described associated with Bell's Palsy.
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PMID:SIADH in the context of localized Herpes-Zoster infection. 3329 33