Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Conflicting opinions exist concerning the use of various birth control methods for women suffering from kidney diseases. Some researchers think kidney diseases are a contraindication for the use of IUD; since IUDs may cause inflammatory processes; others think that preventive therapy of extragenital diseases may make the use of IUD possible. The article studies the functional condition of the urinary system and various hormone levels (renin, aldosterone, vasopressin, cortisol) in women using an IUD. The selections of hormones was based on their role in regulating the water-salt exchange before disturbed in pathologic kidney patients. 43 women aged 19-30 were monitored before insertion and 6 months after insertion of an IUD. 20 women suffered from chronic pyelonephritis, 13 from a latent form of chronic glomerulonephritis; the control group consisted of 10 healthy women. All had previously borne children or had an induced abortion. Besides radioisotopic and radio-immunologic testing, such clinical indicators as bilirubin concentration, cholesterol, and urea in the blood, were determined. Some dependencies were found: for chronic pyelonephritis a positive correlation between the concentration of vasopressin and aldosterone, vasopressin and cortisol, and cortisol and the amount of leukocytes; for chronic glomerulonephritis, a positive correlation between aldosterone concentration and arterial pressure, cortisone level and amount of protein in the urine and concentration of vasopressin and amount of erythrocytes in the urine. The reaction of the kidneys to IUD-induced aseptic inflammatory processes in the uterus is more pronounced for healthy women and women suffering form chronic pyelonephritis, than for women with latent chronic glomerulonephritis, as demonstrated in the test by a reduction in cortisol concentration. The minor changes of the renal functions noticed in healthy and, to a somewhat larger degree, in women from chronic pyelonephritis do not constitute a contraindication for IUD usage and, for latent forms of chronic glomerulonephritis, the IUD is preferred. The functional condition of the kidneys of women suffering from chronic pyelonephritis who use an IUD should be tested by using dynamic scintigraphy.
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PMID:[Function of the kidneys and the renin-aldosterone system in women before and after use of intrauterine contraceptive devices]. 332 76

In two from 3 hyperkalemic patients with chronic glomerulonephritis associated with suppressed aldosterone production ("selective hypoaldosteronism") fractional free water excretion increased and urine osmolality decreased during sodium (Na) restriction. In one of the patients with severe renal concentrating defect in combination with partial vasopressin deficiency polyuria was paradoxically accentuated by lowered Na intake. Na restriction induced 1. a dramatic increase in plasma aldosterone levels, 2. a decrease in glomerular filtration rate associated with a marked disturbance in the glomerulotubular balance resembling to the effects of volume expansion, and 3. a decrease in urinary arginine vasopressin excretion. Paradoxical enhancement of water excretion was explained by increased delivery of filtrate into the distal nephron, increased abstraction of Na from the tubular fluid together with insufficient water permeability of the collecting tubules and lowered vasopressin production.
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PMID:Free water excretion due to suppressed vasopressin and stimulated aldosterone during sodium restriction in hypoaldosteronemic renal failure. 712 44

The effects of an ACE-inhibitor (ramipril), a calcium antagonist (felodipine) and placebo on glomerular filtration rate (GFR), urinary albumin/creatinine ratio, blood pressure (BP) and vasoactive hormones were investigated in a randomized, prospective, double-blind, placebo-controlled study of patients with chronic glomerulonephritis and hypertension, with measurements at entrance and after 12 and 24 months. In total, 33 patients were included: 21 completed the study with 7 patients in each group. GFR was measured as 51Cr-EDTA clearance and the vasoactive hormones with radioimmunoassays. The reduction in GFR was significantly more pronounced in the felodipine group (-7 ml/min) than in the ramipril group (0 ml/min) but the same as in the placebo group (-6 ml/min). The urinary albumin/creatinine ratio was significantly more reduced in the ramipril group (-74 mg/mmol) than in the placebo group (-11 mg/mmol), which did not deviate from the felodipine group (-10 mg/mmol). BP was significantly reduced by ramipril and felodipine, but not by placebo. Angiotensin II and aldosterone in plasma increased or tended to increase in the felodipine and placebo groups, but were unchanged in the ramipril group. Endothelin increased only in the placebo group, and vasopressin, atrial natriuretic peptide, and brain natriuretic peptide were not significantly changed in any of the groups. It is concluded that ramipril seems to be superior to felodipine in chronic glomerulonephritis owing to better preservation of GFR.
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PMID:A comparison of the effect of ramipril, felodipine and placebo on glomerular filtration rate, albuminuria, blood pressure and vasoactive hormones in chronic glomerulonephritis. A randomized, prospective, double-blind, placebo-controlled study over two years. 945 89

We report the first case of the syndrome of periodic adrenocorticotropin (ACTH) and vasopressin (ADH) discharge associated with focal glomerulosclerosis. Approximately 30 cases of this syndrome have so far been reported in Japan, but no cases associated with renal dysfunction have yet been reported. The patient, a 10-year-old Japanese boy, was referred to our hospital because of recurrent attacks of vomiting. He was diagnosed as having this syndrome from clinical and laboratory findings. While various drugs were tried to manage his vomiting attacks, only valproic acid appeared to be effective in reducing the frequency of the attacks. Chronic nephritis was manifested when the patient was 12 years old, which required treatment with continuous ambulatory peritoneal dialysis. Valproic acid was proved to be effective in reducing the number of attacks over 4 months.
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PMID:Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. 989 98