Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Varicella (chickenpox) is sometimes associated with serious complications characterized bp changeable frequency in different ages. We describe a case of varicella with contemporary presence of several complications: serious impetigo , conjunctivitis, pneumonia, hepato-encephalic disease (probable Reye syndrome). This case is interesting because after adequate rehydration and normalization of electrolytes we registered a remarkable fall of plasmatic sodium and chloride as a result of hemodilution probably due to a syndrome of inappropriate secretion of antidiuretic hormone, confirmed by values of plasmatic and urinary osmolarity and of urinary electrolytes.
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PMID:[Probable ADH inappropriate secretion syndrome in varicella]. 237 64

Nineteen children aged four months to 15 years with diabetes insipidus (DI) secondary to severe brain insults were studied. The main primary brain insult was severe head injury in 12, anoxic ischemic brain damage in four, encephalitis in two, Reye's syndrome in one. Sixteen children died, and three survived. The time from insult to onset of polyuria varied from several hours to one month, and was significantly shorter in head trauma patients, 1.8 +/- 0.9 vs. 9.3 +/- 1.9 days for patients with anoxic ischemic brain damage (p less than 0.03). Twelve of the 19 patients met the criteria for brain death at onset of DI. Treatment by appropriate fluids and vasopressin resulted in resolution of polyuria and increase in urine osmolality. Ten patients developed DI while being treated with dopamine for hemodynamic support. In two of these patients, the cessation of dopamine was time-related to the resolution of DI. Our results indicate that as many as 15% of children with DI (with 95% confidence) following severe brain injury may survive. Hence, despite the overall poor prognosis, its occurrence does not necessarily indicate brain death.
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PMID:Diabetes insipidus in severely brain damaged children. 322 Nov 43

The operative management of stress ulcer in children is controversial. Between the years 1969 and 1981, ten children were operated on at the Babies Hospital for stress ulcer. Their illnesses included connective tissue disorders (3), sepsis (2), Reye's syndrome (1), hemolytic uremic syndrome (1), leukemia (1), closed head injury (1), and renal failure (1). In those with bleeding (8), aggressive conventional medical management was attempted prior to operation. Four children also received intravenous cimetidine. Four patients underwent embolization of a feeding artery and/or selective vasopressin infusion. In those patients who perforated (2), operation was performed after a brief period of resuscitation. Ten patients underwent 11 operations. In those who bled, multiple ulcerations were the most common finding. Operative procedures consisted of partial gastrectomy and vagotomy (4), partial gastrectomy alone (2), and vagotomy and pyloroplasty (2). One child who underwent vagotomy and pyloroplasty required partial gastrectomy for recurrent bleeding. Of the two children who perforated, one was managed by plication and the other by partial gastrectomy. There were two deaths (20%), both occurring in patients who had undergone gastrectomy. One survivor has mild dumping. This experience suggests that in children (1) stress ulcers are commonly multiple when associated with major medical illnesses; (2) partial gastrectomy with or without vagotomy affords maximum protection against recurrent bleeding; (3) lesser procedures are effective for solitary bleeding duodenal ulcers or perforation; and (4) selective arterial embolization or vasopressin infusion are unreliable methods for controlling bleeding.
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PMID:Operative management of stress ulcers in children. 709 47