Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with localized herpes zoster is rarely reported and may be under-appreciated. We describe two diabetic men with herpes zoster ophthalmicus (HZO) who developed hyponatremia (114 and 116 mmol/L) during acute illness. Both were euvolemic and had elevated urine osmolality (435 and 368 mmol/kg.H(2)O) and sodium (Na(+)) concentration (61 and 63 mmol/L) along with normal cardiac, renal, liver, and endocrine function consistent with the diagnosis of SIADH. Thorough investigation for other causes of SIADH, including detailed physical examination, laboratory studies, and computed tomography of the brain, chest, and abdomen, were negative. Despite antiviral therapy (acyclovir) for herpes zoster, ophthalmoplegia, keratitis, and post-herpetic neuralgia (PHN) developed. Even with fluid restriction and high salt diet, SIADH lasted for 3 to 4 months and resolved concomitantly with resolution of PHN, suggesting an association between SIADH and HZO. These two cases raise the potential for herpes zoster infection, especially HZO, to involve the regulatory pathway of ADH secretion, contributing to SIADH. The presence of PHN, which reflects greater neural damage may, at least in part, explain the prolonged ADH secretion and hyponatremia.
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PMID:Syndrome of inappropriate secretion of antidiuretic hormone associated with localized herpes zoster ophthalmicus. 2087 95

The uncommon association between the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and localized Herpes-Zoster infection has been reported in only 16 cases in the literature. We present a case of a patient with Herpes-Zoster Ophthalmicus associated with Bell's Palsy who developed new-onset hyponatremia with criteria for SIADH. The patient was euvolemic and his laboratory results showed a concentration of serum sodium of 127 mmol/L, a serum osmolality of 266,9 mOsm/kg, a urinary osmolality of 259 mOsm/kg and a urine sodium concentration of 67,99 mmol/L. After excluding other possible causes, we concluded the diagnosis of SIADH secondary to the viral infection. He was treated with intravenous acyclovir for seven days, systemic corticoids and topical eye treatments. The vesicular lesions resolved with treatment and the serum sodium concentration progressively returned to normal levels, with a value of 136 mmol/L at discharge. Some complications further developed included herpetic keratitis and a corneal ulcer of the right eye. SIADH secondary to localized Herpes-Zoster is a rare entity, but it is important to be recognized by clinicians. This clinical case reinforces the hypothesis of the existence of a relationship between these two diseases, being the only case described associated with Bell's Palsy.
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PMID:SIADH in the context of localized Herpes-Zoster infection. 3329 33