Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of congenital hypothyroidism on both the structure and function of the renal medulla were studied by comparing, in 1-month old rats, the structural features of collecting tubules with the capacity of vasopressin to bind membrane preparations and the related adenylate cyclase activation. With the exception of a reduced caliber, hypothyroidism had no effect on the density, total number, distribution of tubules according to epithelial thickness, or on the number of epithelial cells, or their area. The binding capacity of vasopressin and the related adenylate cyclase activation were equally reduced by about 50%, without changes in (i) the basal or guanylyl-imidodiphosphate (Gpp(NH)p)-stimulated adenylate cyclase activities, (ii) the apparent dissociation constant (KD) of labelled vasopressin from its specific receptor or (iii) the apparent activation constant (Kact) of vasopressin for adenylate cyclase. Taken together, these results clearly demonstrate that congenital hypothyroidism exerts a direct influence on the developing responsiveness of the renal medulla, mainly by reducing the density of active hormone receptors per cell, instead of reducing cell number or cell membrane area.
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PMID:Comparative study of collecting tubules and vasopressin binding capacity in the renal medulla of developing hypothyroid rat. 297 64

Postnatal development of glycogen phosphorylase activation by the cAMP-independent pathway was examined in isolated rat hepatocytes from control and propylthiouracil-treated congenital hypothyroid rat pups. At 5 days postnatum there was complete phosphorylase activation by beta-adrenergic stimulation, glucagon, and the calcium ionophore A23187, but no activation by alpha-adrenergic stimulation. Activation of phosphorylase by angiotensin or vasopressin was less than in hepatocytes from adult rats (P less than 0.01). At 28 days postnatum activation by all of these hormones was complete. In the propylthiouracil-treated group hormone responsiveness was similar to the control at 5 days postnatum. However, alpha-adrenergic (P less than 0.025), angiotensin, and vasopressin (P less than 0.05) activation was decreased at 28 days postnatum, and beta-adrenergic, glucagon, and A23187 activation was complete. The attenuated responses were restored by thyroxine replacement from 15 days postnatum. [32P]Pi incorporation into phosphatidylinositol by epinephrine and vasopressin in 28-day propylthiouracil-treated rats was lower than the control (P less than 0.01). We speculate that the diminished phosphorylase response of hepatocytes to alpha-adrenergic, vasopressin, or angiotensin stimuli in the early neonatal period could be related to low receptor numbers and the weaker phosphoinositide response during this period. Also, the depressed phosphorylase response to alpha-adrenergic, vasopressin, and angiotensin stimulation in congenital hypothyroidism at 28 days postnatum could be related to a decrease in number of plasma membrane receptors for these agonists.
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PMID:cAMP-independent stimulation of glycogen phosphorylase in newborn rat hepatocytes. 298 65

1 The effects of congenital hypothyroidism on the postnatally developing hypothalamus and, particularly on the developing magnocellular nuclei and their vasopressinergic neurons, were studied by means of complementary approaches, such as histology, biochemistry and immunocytochemistry. 2 In normal rat, all the results show a precocious development of hypothalamus, and particularly of its magnocellular nuclei. 3 In hypothyroid rat, in showing that the nucleic acid and protein content of hypothalamus is diminished by the same magnitude than its wet weight, the results display a normal average cellularity and cell size. In the magnocellular nuclei of 10, 20 and 30 day-old rats, the neuronal density and cell size appear to be unaffected, except for the NSO at 35 days of age in which the two parameters are increased and decreased, respectively. With respect to vasopressinergic neurons in 35 day-old rats, their density and percentage in total cell population, as well as the axonal density are somewhat increased, the greater differences always significant being shown only in the NPV. Whatever the nuclei considered, the density of axonal varicosities does not differ from normal value. Finally, the vasopressin concentration of hypothalamus is significantly increased. Thus, it may be concluded that the mainly prenatal development of these vasopressinergic hypothalamic nuclei seems to be relatively spared from neo- and postnatal thyroid deficiency.
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PMID:[Histological, biochemical and immunocytochemical data on the postnatal development of the hypothalamic magnocellular nucleus in the congenital hypothyroid rat]. 343 Mar 63