Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A prospective study was undertaken to determine whether there was a relationship between the pharyngeal flap operation and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). From August 1982 to November 1983, 25 patients underwent pharyngeal flap procedures. They were compared to a control group made up of five patients who underwent major cleft lip revisions. Twelve of the twenty-five patients (48%) who underwent pharyngeal flap procedures had inappropriately elevated serum ADH levels, low serum osmolality, and hyponatremia in the postoperative period. There was a statistically significant (p less than 0.001) drop in the serum sodium levels in the pharyngeal flap group from the preoperative to postoperative period. There was neither a statistically significant change in the serum sodium levels nor inappropriate elevation of ADH levels in the control group. Two patients who underwent pharyngeal flap procedures developed SIADH. To our knowledge this complication has not been reported in association with the pharyngeal flap operation. No specific causes were found that would explain why SIADH developed.
Cleft Palate J 1985 Apr
PMID:The syndrome of inappropriate secretion of antidiuretic hormone in the pharyngeal flap operation. 385 90

A case of the inappropriate secretion of antidiuretic hormone syndrome (SIADH) associated with uneventful repair of a cleft palate in a child with Pierre Robin syndrome is reported. Excess secretion of ADH is seen with pulmonary disease, intracranial infections, and trauma and as a side effect of numerous drugs. Symptoms may be vague but ultimately progress to seizure or coma. Diagnosis is made by confirming hyponatremia and serum hyposmolality in the presence of less than maximally dilute urine with relative sodium wasting. Treatment usually consists of reversing the underlying disorder, fluid restriction, and occasionally hypertonic saline or drug administration. Because of its association with neurological disorders, SIADH should be considered in any patient with an unexplained change in neurological symptoms.
 ...
PMID:The syndrome of inappropriate secretion of antidiuretic hormone associated with cleft palate: report of a case and review of the literature. 636 9

Holoprosencephaly is a developmental defect caused by incomplete cleavage of the embryonic forebrain structures during early embryogenesis. We describe a 3-month-old boy with median cleft palate, surgically reconstructed cleft lip, hypotelorism with a flat nose, cryptorchidism, clubfoot, and microcephaly. During the laboratory investigation, his blood sodium level was 154 mmol/L and urine specific gravity was 1.007. Serum osmolarity was 317 mOsm/kg and urine osmolarity was 268 mOsm/kg. Given these findings and the clinical response to vasopressin, diagnosis of central diabetes insipidus was made. Magnetic resonance imaging revealed semilobar holoprosencephaly. The patient responded very well to vasopressin treatment with restoration of serum electrolytes, which remained within normal limits on follow-up. In case of midline facial defects accompanied by hypotelorism with or without developmental delay, the brain should be imaged to confirm its morphology and investigations should be directed by a high index of suspicion of associated endocrinologic dysfunctions.
 ...
PMID:Holoprosencephaly and diabetes insipidus in a 3-month-old infant. 1807 12