Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01185 (
vasopressin
)
23,126
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Caldendrin is a neuronal calcium-binding protein, which is highly enriched in the postsynaptic density fraction and exhibits a prominent somato-dendritic distribution in brain. Two additional splice variants derive from the
caldendrin
gene, which have unrelated N-termini and were previously only detected in the retina. We now show that these isoforms are present in
neurohypophyseal
axons and on secretory granules of endocrine cells. In light of the described interaction of the Caldendrin C-terminus with Q-type Ca(v)2.1 calcium channels these data suggest that this interaction takes place in
neurohypophyseal
axons and pituitary cells indicating functions of the short splice variants in triggering Ca2+ transients to a vesicular target interaction.
...
PMID:Association of Caldendrin splice isoforms with secretory vesicles in neurohypophyseal axons and the pituitary. 1286 Apr 11
