Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper reports studies of the effects of original analogs of the C-terminal fragment AVP(6-9), D-MPR and D-MPRG, on the development of a conditioned active avoidance response in rats; agents were given intranasally over a wide range of doses. The most effective does of D-MPR was 0.1 microgram/kg, and the most effective dose of D-MPRG was 0.01 microgram/kg. The tri- and tetrapeptide doses were 10 and 100 times smaller than the dose of arginine-vasopressin used in analogous experimental conditions. The tri- and tetrapeptide accelerated development of the active avoidance conditioned response, affecting both formation of the habit and consolidation of the memory trace. The actions of these peptides were mainly on perception processes, i.e., isolation of the concrete stimulus from the environment, and assessment and remembering of its biological significance.
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PMID:The effects of analogs of the C-terminal fragment of arginine-vasopressin on the dynamics of development of a conditioned active avoidance response in rats. 1043 10

The effects of an arginine-vasopressin fragment, Ac-D-MPRG, on the movement activity and orientational-investigative activity of white rats were studied. Peptide was given intranasally at doses of 0.001, 0.01, 0.1, 1, and 10 micrograms/kg 1 h before testing. All peptide doses increased vertical movement activity in an open field test and hole board test and decreased grooming levels in both tests. The peptide had no effect on horizontal movement activity. Analysis of these results led to the conclusion that Ac-D-MPRG increases orientational-investigative activity, but, unlike arginine-vasopressin, does not affect non-motivated movement activity.
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PMID:The effects of a novel analog of the C-terminal fragment of vasopressin on the behavior of white rats. 1058 16

This report presents studies on the effects of intranasal administration of five doses (0.001, 0.01, 0.1, 1, and 10 microg/kg) of a new analog of arginine-vasopressin fragment AVP(6-9), i.e., D-MPRG, on the learning ability of rats with positive and negative reinforcement. All doses of the peptide improved learning. The most effective dose was 0.01 microg/kg, at which the peptide accelerated the acquisition of a conditioned active avoidance reflex both when given 1 h before and when given immediately after training sessions. The peptide had greater effects when animals were trained with negative reinforcement. Analysis of the results suggests that the action of D-MPRG is mainly on perception processes, i.e., extraction of the conditioned stimulus from the environmental surroundings and evaluation and enhancement of its biological significance. In addition, this peptide prevented extinction of the acquired habit and improved the processes of consolidation, though this effect was weaker than its effect on perception.
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PMID:Improvements in the selective perception and training of rats using an original analog of the C-terminal fragment of vasopressin. 1087 34