Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The uterine and cardiovascular effects of fenoterol, hexoprenaline, ritodrine and salbutamol, given as intravenous infusions in equivalent and therapeutic dosages in oxytocin-induced labour, were studied and compared. All the drugs were effective in reducing the uterine activity to less than 30% of the original. The effect on the cardiovascular system was to produce a moderate tachycardia and a widening of the pulse pressure by raising the systolic and decreasing the diastolic blood pressures.
 ...
PMID:Uterine and cardiovascular effects of beta2-selective sympathomimetic drugs administered as an intravenous infusion. 1 1

Effects of methyl O-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400), a new antihypertensive agent, on the peripheral nervous system in mice, rats and guinea pigs were investigated and compared with effects of reserpine and rescinnamine. Oral administration of CD-3400 in doses from 40 to 320 mg/kg revealed a miotic action and such was weaker than that seen with reserpine and rescinnamine. The intestinal propulsion in mice was accelerated by pretreatment with reserpine, but no so with CD-3400. In isolated guinea pig vas deferens, CD-3400 at a concentration of 1 X 10(-5) M inhibited on norepinephrine-induced contraction non-competitively. However, in insolated rat vas deferens pretreated with CD-3400 (1 mg/kg, i.p.) for 5 days, norepinephrine-induced contraction was potentiated and this effect was weaker than that seen with reserpine and rescinnamine. In isolated rat vas deferens pretreated with CD-3400 for 1, 2 and 5 days,, the contraction induced by tyramine (3 X 10(-5)M) was significantly inhibited. The effect was qualitively similar to those of reserpine and rescinnamine. The intravenous administration of these three rauwolfia alkaloids in doses of 1, 2 and 4 mg/kg had no effect on the spontaneous movement of rat uterus. In isolated rat uterus pretreated with CD-3400, no significant effect was observed on oxytocin- and isoproterenol-induced responses. The peripheral actions of CD-3400 are attributed to a deterioration in the function the sympathetic nerve resulting in depletion of catecholamine stores. Efect of CD-3400 were slightly weaker than those of reserpine and rescinnamine.
 ...
PMID:[Effects of methyl O-(4-hydroxy-3-methoxycinnamoly)reserpate (CD-3400) on the peripheral nervous system: especially on the smooth muscle organs]. 1 72

12 prealbumines of rat brain water-soluble fraction were studied. Neither lipid components nor carbohydrate ones were found out in the proteins. Three of the proteins appeared to be RNA-proteids. Their subcellular distribution was investigated. The effects of temperature, salts, acids and ethanol on disc electrophoretic spectrum of brain prealbumines were closely observed. The amino acid composition, properties, compartmentation, tissue and species specificity of one of the prealbumines were studied in detail. The protein is marked as BTB-protein, as it migrates under disc electrophoresis in 7,5% polyacrylamide gel with the "witness" front of bromothemol blue (BTB). The content of BTB-protein is 0.06--0.08 gr per 100 gr of wet tissue. The protein is RNA-proteid. Its molecular weight is 10,000--20,000. BTB-protein contains 42 mole % of acidic amino acids and 5.4 mole % of alkaline ones. The protein was found in nuclear and cytoplasmic fractions. It is mainly an all-organs protein. Small amount of this protein is found in blood serum. BTB-protein can be found on the disc electrophoregramms of embryo and newborn rats brain proteins, as well as of the brain of other mammals, birds and amphibia. BTB-protein is resistant to boiling and to the effects of salts, acids, ethanol. It is suggested that BTB-protein has heterogenous structure and may be of neurophysin nature.
 ...
PMID:[Investigation of rat brain prealbumins]. 1 53

The question whether the termination of a breech pregnancy by a programmed breech delivery would reduce the fetal risk was investigated. In 71 of 433 singleton breech deliveries (16%) the breech delivery was induced by oxytocin infusion. There were 38 primigravidas and 33 multi-gravidas. The Apgar and pH values showed the same results as in 3904 vertex deliveries with spontaneous onset of labour. The duration of labour was shortened. The incidence of Caesarean Section in programmed breech deliveries was 9.86%. All 71 infants were mature and healthy. There were no perinatal deaths. The results show that the fetal risk in breech deliveries is reduced by programmed breech delivery to the same risk as in vertex deliveries with spontaneous onset of labour.
 ...
PMID:[Programmed breech deliveries (author's transl)]. 1 23

The spontaneous contractility of the epididymis in the rat was recorded in vivo and the effects of the neurohypophyseal hormones were studied. Oxytocin (50 muU and 500 muU/100 g body weight) produced a progressive increase in tonus together with an increase in amplitude and frequency of the contractions. Vasopressin (100 muU and 1000 muU/100 g body weight) showed similar effects. No differences were apparent at the doses studied.
 ...
PMID:The 'in vivo' effects of oxytocin and vasopressin on spontaneous contractility of the rat epididymis. 1 18

Prostaglandin F-2 alpha was applied intrapartum in 104 women who (1) had indications for induction of labor (32 of them had premature rupture of the amniotic sac) and (2) had already received ineffective infusions of oxytocin. 80 women (77%) had vaginal deliveries; 24 had to have caesarean sections. Of these 24, however, only 9 were without strong obstetric indications for caesarean section (such as fetal heartbeat, fetal acidity, or intrapartum fever). 75 of the subjects were primiparae; the age range was 16-43. The prostaglandin was in a solution of 10-15 mcg/ml; the infusion rate was 5-22.5 mcg/minute. The mean time from infusion to birth was 180 minutes; mean time from 5-cm cervical dilation to birth was 114 minutes (cervical dilation was 2-3 cm at the beginning of prostaglandin application). No harmful effect on the state of the newborn was observed, as Apgar pH scores were similar to those of children born after spontaneous labor.
 ...
PMID:[Experiences on the effectivity of prostaglandin F2alpha during labor after insufficient effect of oxytocin]. 1 1

The effectiveness of prostaglandin F2 alpha (PGF2a) administered by iv drop infusion to induce labor was studied. The results were compared with those obtained in oxytocin-induced labor. It was determined that PGF2a can without any danger be administered in the induction of labor. The process of labor and the ensuing results indicate that PG is less of a burden to the uteroplacental circulation. In administereing either of the 2 drugs, the principle of applying the "smallest" dose is considered important.
 ...
PMID:[Induction of labor with prostaglandin F 2 alpha (a comparative study using oxytocin and prostaglandin)]. 2 96

The concentration of MSH in serum after estrogen or progesterone injection into gonadectomized rats was measured by a biological assay. Undetectable serum MSH values were found in long-term ovariectomized (OVX) rats. After a single injection of 10 microgram estradiol benzoate (EB) serum MSH exhibited a circadiam rhythm with high levels in the afternoon, while values in the morning were negative. This effect occurred for 4 days following the injection. Progesterone injection into spayed rats also resulted in an increase of serum MSH concentration, but in contrast to the changes observed after EB treatment high values were found in the morning for 3 consecutive days. Afternoon MSH levels were low but measurable. The effect of these steroids on the activity of the hypothalamic enzymes which yielded MIF or MRF upon incubation with oxytocin (OXT) was also studied. Enzymatic activity of both systems was undetectable in OVX rats and was evident after EB treatment. Progesterone increased only the activity of the system which yields MRF. In castrated male rats estrogen elevated baseline MSH levels but a circadian rhythm was not observed, whereas progesterone had no effect. These observations demonstrate a sex difference on steroid-induced MSH release.
 ...
PMID:Effect of estrogen and progesterone on the release of MSH in gonadectomized rats. 2 14

Oxytocin, elevated estrogen-progesterone ratio, fetal corticosteroids, prostaglandins, catecholamines, and changes in uterine blood flow have all been implicated as triggers of labor. In approximately one-third of cases of threatened premature labor contractions stop spontaneously. Thus placebo-controlled randomized trials of any new drug for inhibition of premature labor are necessary, as the spontaneous cessation of contractions always favors the claimed therapeutic efficacy. Alcohol inhibits the release of endogenous oxytocin and has an additional direct effect on the myometrium. In one study alcohol was more effective than placebo in the postponement of delivery. Isoxsuprine, ritodrine, and terbutaline have also been shown to be better than placebo in the inhibition of premature labor, and the beta adrenergic agents appear to be more effective than alcohol. Prostaglandin inhibitors such as indomethacin are currently under investigation. Success is correlated with early administration of the therapy, which requires treating some patients whose contractions might have stopped spontaneoulsy. As different factors may be involved in triggering premature labor, if one therapeutic approach fails another should be initiated promptly.
 ...
PMID:The pharmacologic inhibition of premature labor. 2

The value of a general pH analysis of the artery umbilicalis as a parameter of the postnatal diagnostic of the newborns is shown. The classification of the values in different grades of acidity and the relation to the Apgar score show, that the light and middle-heavy acidoses are not determined sufficiently by the Apgar score. The CTG-monitoring and the stimulation of the Oxytocin had no influence on the frequency of the different grades of the acidity. The meaning of the general blood-gas analysis in the artery umbilicalis for the morbidity of acidity and the check of the obstetrical activity of the clinic is shown.
 ...
PMID:[Significance of a general umbilical-cord pH for the evaluation of acidosis morbidity]. 2 25


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>