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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A type I interferon (IFN) secreted by the trophoblast of early sheep and cow embryos is thought to be responsible for the maternal recognition of pregnancy. The expression of trophoblast IFN is tissue specific and temporally controlled. However, the isolated bovine trophoblast IFN promoter did not confer tissue specificity on the expression of a bacterial chloramphenicol acetyl transferase (CAT) reporter gene, and could not be induced by virus, unlike other type I IFNs. Trophoblast IFN acts locally within the uterus to prevent luteolysis and prolong progesterone secretion. Endometrial IFN receptors are present, and trophoblast IFN decreases expression of endometrial oxytocin receptor and increases expression of endometrial beta 2-microglobulin, MHC class I antigens and Mx (a mediator of IFN antiviral activity) only in the pregnant horn of pregnant ewes with a transected uterus. The primary effect of trophoblast IFN during early pregnancy appears to be an inhibition of oxytocin receptor expression, although studies in ovariectomized ewes suggest that luteal oxytocin may be required to facilitate the inhibition of prostaglandin F secretion by trophoblast IFN. An investigation of the isolated oxytocin receptor promoter should confirm its critical role in the maternal recognition of pregnancy.
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PMID:Trophoblast interferons in early pregnancy of domestic ruminants. 133 57

There were examined the influence the various types of delivery (spontaneous, oxytocin induced, cesarean section) on the value of albumin's (marker of glomerular activity), beta 2-microglobulin's (beta 2-M) (marker of activity proximal renal tubule) and Tamm-Horsfall's protein (pTH) (as a marker of activity distal's renal tubule) excretion in 50 healthy pregnant women without clinical symptoms of nephropathy. There were also estimated creating concentration in plasma and value of creating excretion in urine before and after delivery in every women. There were stated a little increase of albumin and beta 2-microglobulin but proper excretion (pTH) in urine in every group of pregnant women. There were estimated increase of albumin and pTH excretion in urine after spontaneous delivery, oxytocin inducted or cesarean section, particularly in women after cesarean section. The type of delivery had not an effect on the beta 2-microglobulin's urine excretion. The results of conducted researches suggest occurrence of functional changes in both renal glomeruli and tubules in physiologic pregnancy. The type of delivery reveals differentiated in quantity's respect the influence on albumin's and pTH excretion, but it has not an effect on beta 2-microglobulin's urine excretion.
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PMID:[The activity of renal glomeruli and tubules during uncomplicated pregnancy: influence of delivery on urinary excretion of albumin, beta 2-microglobulin and Tamm-Horsfall protein]. 948 Feb 37