Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1. The antagonistic effect of thioglycerol against
oxytocin
and an analogue of
oxytocin
not containing a disulphide bridge (desamino-1-carba-
oxytocin
) has been compared in the rat isolated depolarized uterus.2.
Thioglycerol
clearly differentiated between the two compounds, 40 mM producing a dose ratio of 12 with
oxytocin
but only 1.5 with the carba compound.3. It was confirmed that thioglycerol produces no appreciable destruction of
oxytocin
in vitro.4. The mode of action of thiols in antagonizing specifically S-S polypeptides is discussed. It is concluded that they probably do not produce their effect either by inactivating receptors or by inactivating S-S polypeptides in solution. A possible mechanism is that thiols potentiate the destruction of S-S polypeptides at the receptor site.
...
PMID:Lack of antagonism between thioglycerol and an oxytocin analogue not containing a disulphide bond. 542 Jan 46
