Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phospholipase C (Clostridium welchii and Bacillus cereus) treatment of lactating rabbit mammary gland membranes (140,000 g pellet and sucrose density gradient purified plasma membranes) resulted in a large decrease in the binding of [3H]oxytocin to these subcellular fractions. This decrease was not due to a solubilization of oxytocin receptors but was the result of the removal of phospholipids which may participate in the hormone-receptor interaction. Phospholipase C treatment of the membrane fractions resulted in a dose-dependent removal of different classes of phospholipids. Sphingomyelin, phosphatidylcholine and phosphatidylethanolamine were removed by phospholipase C (C. welchii and B. cereus) treatment. No significant change was observed in the content of phosphatidylinositol. Phospholipase C from B. cereus reduced the content of phosphatidylserine, while the enzyme from C. welchii did not.
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PMID:The role of phospholipids in the binding of oxytocin to its receptors in lactating rabbit mammary gland. 629 74