Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To observe the clinical effects and the mechanism of Chanlibao (CLB, a preparation of Chinese herbal medicine) in accelerating second stage of labor, primiparae were divided into 3 groups at random. CLB or oxytocin (OTC) was given to the CLB group (n = 80) and the OTC group (n = 52) respectively. The third group served as controls (n = 29). The control group consisted of women experiencing natural labor and to whom no drug was given. The time of second stage of labor and prognosis of mother and newborn of different groups were observed and compared. And intrauterine pressure and fetal heart rate were monitored by means of electronic monitoring. Isolated uterine muscular tissue was used to observe the reactivity to CLB. The results showed that the time of second stage of labor and postpartum hemorrhage in the CLB group were less than those in the control group and the average intrauterine pressure in the former was higher than that in latter, so was the contraction strength of isolated uterine muscle, but with no difference as compared with the OTC group. No side effect of CLB was found. It is concluded that CLB could obviously strengthen uterine contraction and accelerate second stage of labor. Moreover, it is inexpensive, convenient and free of side effect. It can be used as a new, safe and effective alternative for improving prognosis of mother and newborn, especially those not indicated for oxytocin or profuse infusion.
 ...
PMID:Clinical effects and mechanism of chanlibao in accelerating second stage of labor. 1284 Aug 59

The goal of this study was to determine the effects of the length of the preovulatory phase on genital blood flow and mRNA expression of endometrial hormone receptors in cattle (Bos Taurus). Ovulation was synchronized in 50 Holstein-Friesian cows using a modified Ovsynch (ovulation synchronization) protocol, in which the second gonadotropin-releasing hormone (GnRH) administration was given 40h (G40, n=17) or 60h (G60, n=16) after the prostaglandin F(2alpha) (PGF(2alpha)) administration. The third group (S, n=17) did not receive a second GnRH administration. Transrectal color Doppler examinations were carried out 24h before (Day -1) and on Day 7 after ovulation (Day 0). Follicular size (FS) and luteal size (CLS) were quantified by measuring the areas of these structures on cross-sectional B-mode ultrasound images. Follicular blood flow (FB) and luteal blood flow (CLB) were quantified by determining the colored areas of these structures. Uterine blood flow was measured using the time-averaged maximum velocities (TAMVs) and the pulsatility indices (PIs) of both uterine arteries. Endometrial mRNA transcript abundance of estrogen receptors alpha and beta as well as oxytocin and progesterone receptor were determined on Days -1 and 7 in G40 and G60 cows. In all cows, plasma progesterone (P(4)) values were measured on Day 7. On Day -1, FS and FB values were lower (P < or = 0.05) in G40 cows compared with those in S cows but did not differ (P>0.05) between G60 cows on the one hand and G40 cows and S cows, respectively, on the other hand. On Day 7, CLS and P(4) did not differ (P>0.05) between cows of Groups G40, G60, and S; CLB was lower (P< or =0.05) in G40 cows than in G60 and S cows, but no difference (P>0.05) occurred between G60 and S cows. The uterine TAMV and PI values did not differ among the three groups (P>0.05). Gene expression of hormone receptors did not differ (P>0.05) between Groups G40 and G60 on Days -1 and 7. Results of this study indicate that a shortened preovulatory follicle phase primarily affects ovarian but not the measured uterine events in cows undergoing synchronization of ovulation.
 ...
PMID:Effects of a shortened preovulatory follicular phase on genital blood flow and endometrial hormone receptor concentrations in Holstein-Friesian cows. 1989 33