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Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oxytocin
has been previously shown to augment GnRH-stimulated LH release. However it is currently unknown which intracellular mediators participate in the process. In this study, after preincubation with
oxytocin
for 3 hours, quartered pituitaries were stimulated for 15 minutes with GnRH. The effects of diBucAMP, a cell permeable analog of cAMP, and
DDA
, an adenyl cyclase inhibitor, on the augmentation by
oxytocin
were investigated. Although addition of diBucAMP increased GnRH-stimulated LH release, it inhibited the augmentation by
oxytocin
of the response to GnRH. On the other hand addition of
DDA
induced an increased augmentation by
oxytocin
. These results indicate that intracellular cAMP inhibits the augmentory activity of
oxytocin
, and suggest that
oxytocin
modulation of GnRH action in vivo would be optimal when the hormonal milieu results in reduced levels of cAMP.
...
PMID:Oxytocin augmentation of gonadotropin-releasing hormone-stimulated luteinizing hormone release is modulated by cyclic AMP. 876 Oct 24
