Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of
SKF 525A
(20 mg/kg i.v.) on pressor responses of various origin was studied.
SKF 525A
abolished or markedly reduced the pressor responses to ganglionic stimulants (DMPP and McN-A-343), but potentiated those to noradrenaline (in normal and pithed animals), adrenaline, tyramine,
oxytocin
and carotid occlusion. After recovery of the pressor effect of McN-A-343 from the
SKF 525A
-induced suppression, the pressor effect of noradrenaline was still further enhanced. The abolition of the pressor responses to ganglionic stimulants is due to the ganglion and adrenal-medullary blocking action of
SKF 525A
. This action of
SKF 525A
is of secondary importance for its potentiating effect. It is tentatively suggested that for the
SKF 525A
-induced potentiation a partial depolarization of arterial smooth muscle membrane resulting from a prolonged release of subthreshold concentrations of catecholamines from tissue stores, may be of primary importance.
...
PMID:Potentiation by SKF 525A of the pressor responses to catecholamines, oxytocin and carotid occlusion in rats. 646 7
