Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inhibitory effects of Partusisten, Dilatol, Papaverin and Magnesium-sulfat on the activity of smooth muscle were tested in vitro on 18 isolated stripes of rats uteri, exhibiting both a high sensitivity against oxytocin and a distinct spontaneous activity. Minimal inhibitory concentrations of all drugs tested were determined, and their influence on the frequency and amplitude of contraction as well as on lag phase between inhibition and onset of spontaneous activity were registered. Basing on these experimental data conclusions were drawn concerning their clinical relevance.
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PMID:[The effect of partusisten, dilatol, papaverine and magnesium sulfate on uterine smooth muscle in vitro]. 258 61

The objective of this work was to examine the smooth muscle relaxing properties of antioquine, compared to papaverine, in isolated rat uterus. The results obtained show that both antioquine and papaverine are capable of relaxing sustained contractions induced by Ca2+ in K-depolarizing solution as well as the spontaneous activity of rat uterus. Antioquine (0.1 mM, 0.5 mM and 1 mM) also induces a displacement to the right of the dose-response curves to Ca2+, and the antagonism was not competitive. Papaverine produced a decrease in the frequency and amplitude of contractile responses induced by oxytocin, and these inhibitory effects were observed regardless of whether papaverine was added before or after the induced contractions. On the other hand, antioquine only modified the frequency of contractile responses to oxytocin or desynchronized cumulative dose-response curves to oxytocin when the uterus was preincubated with this alkaloid before addition of the agonist. These experiments suggest that the relaxant effects produced by antioquine may be due to the blockade of calcium movements across the cell membrane, mainly through voltage-operated channels, whereas papaverine affects Ca2+-entry both through VOCs and through ROCs.
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PMID:Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity. 273 Feb 36

Our study concentrated upon the modifications of some parameters which characterize uterine smooth muscle contractile activity under the action of active substances. We studied the isotonic contractions of the uterine smooth muscle in a classical organ bath in which we introduced some contracting and relaxing substances. At the beginning, we introduced Oxytocin to determine uterine smooth muscle contractions. After that, we added relaxing substances (Papaverin, Diazepam, Terbutalin, Isoxuprin, Hexoprenalin) in the organ bath, and then, in another protocol, we added combinations of two relaxing substances. We determined for each wave some parameters: minimum, mean, maximum and net amplitude, wave area and duration, the interval between waves, the time while the curve increases from the minimal value of the amplitude to the maximum value, the frequency of contractile waves. For each parameter we determined the variance coefficient (C.V. %), which reflects the regularity of the uterine activity. We observed a regularizing effect of the uterine activity after administration of some active substances. The smallest variance coefficient (C.V. %) was found for HEXO + PAP combination (mean value for C.V. % is 4.71%).
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PMID:The regularizing effect of some active substances upon uterine smooth muscle contractile activity. 1106 7

In the present paper, we examined a mechanism of the papaverine induced relaxation in the smooth muscle of non-pregnant rat uterus. The hyperosmotic 65 mM KCl (H-65K+)-or oxytocin-induced contraction in the uterus was inhibited by an addition of papaverine in a concentration-dependent manner. Papaverine did not increase both cAMP and cGMP contents in the uterus in the presence of H-65K+ or oxytocin. In fura 2 loaded muscles, papaverine did not affect an increase of [Ca2+]i level by high K+ or oxytocin. In permeabilized muscles, papaverine had no effect on the Ca2+-induced contraction. H-65K+ and oxytocin increased the rate of oxygen consumption 1.8 and 1.5 times higher than that in the resting condition, respectively. The increase of oxygen consumption in the H-65K+ or oxytocin was significantly inhibited by papaverine (1-100 microM). These results suggested that papaverine inhibits smooth muscle contraction mainly by inhibition of mitochondrial respiration in rat uterus as well as guinea pig ileum, which shows a highly spontaneous activity and a highly metabolic dependency of a contraction.
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PMID:Mechanism of relaxant response to papaverine on the smooth muscle of non-pregnant rat uterus. 1108 80