Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pharmacological effects of oxamate on the spontaneous or the oxytocin-induced motility of isolated rat uterus in a solution with lactate as the sole external substrate were investigated during estrus, following ovariectomy, and after castration accompanied with estradiol replacement therapy. Uterine preparations were tested for mechanical activity (isometric-developed tension and the frequency of contractions). Initial oxytocin-induced activity of the uterus of rats in induced estrus was significantly greater than spontaneous activity (p.01). Oxamate added to the suspension was ineffective in modifying this activity. In castrate rats, however, the addition of oxamate to the medium significantly reduced oxytocin-driven and spontaneous motility. Those ovariectomized rats receiving replacement therapy were also resistant to oxamate effects. The effects of oxamate upon pyruvate levels of oxytocin-exposed uterine tissue were also determined. In the presence of oxamate, levels of uterine pyruvate in all the hormonal conditions were significantly lower than in controls (p.001).
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PMID:Effects of oxamate, an inhibitor of lactate dahydrogenase, upon the spontaneous or oxytocin-induced motility and over pyruvate levels of uterine horns isolated from ovariectomized or estrus rats. 103 72