Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levels of prekallikrein and HMW kininogen that had increased during pregnancy decreased with start of labor. The role of the kinin-forming system with oxytocin in the mechanism of labor was suggested from the results of decreased prekallikrein and HMW kininogen, appearance of a free kallikrein-like enzyme during labor, and from the case of arrested labor in which both prekallikrein and HMW kininogen were markedly decreased. Prekallikrein was markedly decreased in patients with acute obstetrical DIC and severe toxemia of pregnancy. The excessive activation of prekallikrein in DIC seemed to be of help for understanding such clinical signs as shock, abnormal labor, and increased permeability in obstetrical DIC.
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PMID:The kinin-forming enzyme system in pregnancy and obstetrical DIC. 642 Dec 72

A 28-year-old woman, G3P3, who was otherwise healthy and had taken no medication and had no known allergy, was admitted to our hospital for delivery after a normal pregnancy. An epidural catheter was inserted for analgesia and labour was induced with oxytocin. Two hours later, she suffered a sudden cardiac arrest. She was immediately treated and, since a normal cardiac rhythm and a blood pressure of 90 mmHg has been obtained 30 minutes later, a 3750 g child was delivered by caesarean section. Soon after delivery, a life-threatening uterine haemorrhage appeared, due to DIC. Evolution was favourable, after bilateral uterine arteries embolization had been performed. The diagnosis of amniotic fluid embolism was established by the clinical course, the absence of local cause and the presence of a large number of amniotic cells in the mother's peripheral blood. Tryptase blood concentration was normal in the mother's blood.
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PMID:[Amniotic fluid embolism: successful evolution course after uterine arteries embolization]. 1207 39

A 34-year-old woman, who had had atonic bleeding six years ago, had selective cesarean section under CSEA. On the operation, atonic bleeding occurred and persisted. Though we used uterine contracting agents (oxytocin, ergometrine), the bleeding volume exceeded 2,000 ml and the examination revealed Hb 5.9 g x dl(-1), Ht 19%. We decided to perform emergency hemostatic operation (total hysterectomy) under general anesthesia. During the emergency operation, total blood loss was 5,810 ml and total urine was 205 ml. We transfused packed red cell 16 units, FFP 10 units, and infused fluid 4,650 ml. After the operation, the examination revealed Hb 9.7 g x dl(-1), Ht 27.8%, Plt 7.0 x 10(4) x microl(-1) and obstetric DIC score 10. The patient was treated in ICU under intubation, with anti-DIC drug (ulinastatin 50,000 units). Next day, she was extubated and admitted to the maternity ward. She was discharged on the 7th postoperative day without any complications. In 2010, guideline for obstetric critical hemorrhage was published. The guideline recommends the importance of observing the perioperative change of vital sign (e. g. shock index) and obstetric DIC score. In the obstetric critical hemorrhage, we should take proper and prompt actions in accordance with this guideline.
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PMID:[Case of atonic bleeding managed by emergency total hysterectomy and mass blood transfusion right after the cesarean section]. 2315 7