Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1.10(-7)--1.10(-5) g/ml of isadrine induced a 2-phase hyperpolarization changes of MP of the secretory cell. Propranolol (1.10(-6) g/ml) decreased the amplitude of hyperpolarization response of the MP to oxytocin by 36%; 1.10(-9)--1.10(-8) g/ml of isadrine induced a 42% and 53% decrease respectively, and 1.10(-7)--1.10(-5) g/ml blocked the response of secretory cells to oxytocin. The data obtained suggest that catecholamines can effect the MP by means of interaction with beta-adrenoreceptors of mammary secretory cells.
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PMID:[Effect of isadrine and propranolol on the membrane potential of mammary secretory cells]. 20 73

Direct measurements of cyclic AMP were performed in the isolated epithelium of frog skin. Phosphodiesterase inhibitors (methylxanthines, papaverine) and activators of adenylyl cyclase (oxytocin, catecholamines) significantly increased the cyclic AMP content. Propranolol completely blocked the generation of cAMP induced by beta-adrenergic agonists but had little or no effect on that induced by oxytocin. Phentolamine enhanced the cAMP production by adrenalin and noradrenalin. At supramaximal concentrations, oxytocin and isoproterenol produced similar increments in cAMP, while exposure to both agents roughly doubled the increase in cAMP. The results suggest the presence of independent receptors for oxytocin and catecholamines in frog skin, with additive effects on cAMP generation.
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PMID:Cyclic AMP levels in isolated frog skin epithelium: effects of phosphodiesterase inhibitors, oxytocin and catecholamines. 21 57

The influence of amantadine on the contractile responses of the rat uterus to oxytocin in the presence of several ionic modifications of the external medium was studied both in situ and in vivo. Oxytocic effects of amantadine were observed in vivo (1 and 5 mg/kg), and in vitro (9.3 times 10-7 M to 2.8 times 10-6 M); possible competitive partial potentiation of the contractile effect of oxytocin was also observed. Amantadine, 9.35 times 10-6, 1.3 times 10-5 and 1.8 times 10-5 M, significantly reduced oxytocic activity. Calcium ions antagonized the oxytocic and antioxytocic effects of amantadine. Excess K+ and the presence of Mg2+ ions (1.8 mM/l and 1.08 mM/l respectively) reversed the antioxytocic effect of amantadine. Propranolol also reversed the antioxytocic effect of amantadine. It is postulated that the oxytocic effect of amantadine may be related to antagonism of calcium; antioxytocic activity may be explained by stabilization of the resting cell membrane, inhibiting ionic flow, and also by its catecholamine-liberating activity.
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PMID:The action of amantadine on the rat uterus: its interaction with oxytocin and the effects of several ionic modifications of the medium. 112 78

To measure cholinergic, adrenergic and tryptaminergic receptor activity of formaldehyde (HCHO) in rat uterus, albino rats were treated with 5 and 10 mg/kg, ip HCHO for 30 days. Acetylcholine (ACh) in doses 1.33, 2 and 3 micrograms/ml produced mild to moderate contraction of isolated rat uterus in control group. HCHO had no effect on isolated rat uterus per se, however it reduced ACh and carbachol induced contraction and presence of adrenaline influences in respect of ACh and carbachol activity. Adrenaline per se had no effect in control preparations, but reduced carbachol induced contraction. Propranolol had no effect on rat uterus; but its presence in the bathing medium increased activity of adrenaline. 5-Hydroxytryptamine (5-HT) had no effect of its own on isolated rat uterus but its presence in the bathing medium enhanced contractions of carbachol and oxytocin.
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PMID:In vitro study of rat uterus after chronic formaldehyde exposure. 129 16

Carp (Cyprinus carpio) liver maintained normal glycogen content and enzyme complement for several days in organ culture. Epinephrine-stimulated glycogenolysis, phosphorylase activation, and cyclic AMP (cAMP) accumulation in a concentration-dependent manner with EC50s of 100, 100, and 500 nM, respectively. These actions were blocked by the beta-adrenergic antagonist, propranolol, but not by the alpha-adrenergic antagonist phentolamine. Glycogenolysis and tissue cAMP were uninfluenced by 10(-6) M arginine vasotocin, arginine vasopressin, lysine vasotocin, lysine vasopressin, mesotocin, or oxytocin, but were slightly increased by 10(-5) M isotocin and slightly decreased by 10(-6) M angiotensin II. [125I]-iodocyanopindolol (ICP), a beta-adrenergic ligand, bound to isolated carp liver membranes with a KD of 83 pM. Maximum binding of 45 fmol/mg protein was at 600 pM. Propranolol, isoprenaline, epinephrine, phenylephrine, norepinephrine, and phenoxybenzamine displaced ICP with KDs of 100 nM, 2, 20, 20, 60, and 200 microM, respectively. The alpha-adrenergic antagonists, yohimbine and prazosin, showed no specific binding. These data provide evidence that catecholamines act via beta-adrenergic receptors in carp liver and that alpha-adrenergic receptors are not present. Vasoactive peptides play no significant role in regulation of carp liver glycogenolysis.
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PMID:Hormonal regulation of hepatic glycogenolysis in the carp, Cyprinus carpio. 303 3

The effects of catecholamines and ascorbic acid on cultured bovine granulosa cells have been examined to assess their possible role in the initiation and maintenance of luteal oxytocin secretion. The actions of these agents have also been compared with the previously reported ability of follicular theca tissue to enhance oxytocin secretion. Using granulosa cells cultured in serum-supplemented medium, we observed a highly significant enhancement of oxytocin secretion in the presence of adrenaline and noradrenaline, particularly over the concentration range 1-10 mumol/l. This effect was accompanied by smaller and less consistent changes in progesterone secretion and did not involve any change in the time-course of oxytocin secretion. Acetylcholine was without effect. Ascorbic acid stimulated oxytocin secretion when used alone over a range of concentrations, but was also able to synergize with adrenaline. Lactic acid was ineffective. The stimulation of oxytocin secretion by adrenaline could be blocked by equimolar propranolol, but the stimulation of progesterone was not blocked. Propranolol had a variable effect on the ability of theca tissue to stimulate oxytocin secretion by granulosa cells but the results also suggested the presence of some beta-agonistic activity in the culture medium. We conclude, first, that catecholamines may be involved in the regulation of ovarian oxytocin secretion, secondly, that ascorbate may regulate oxytocin secretion through its involvement in the biosynthesis of oxytocin but also through interaction with catecholamines and, thirdly, that the stimulatory action of theca tissue probably does not involve the action of beta-agonists.
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PMID:Catecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion. 366 32

A distinct decrease of oxytocin was found in the hypothalamus of immobilized rats but not of those exposed to cold. Similarly, the content of oxytocin was lower in the neurohypophysis of rats immobilized for 24 hr but, on the contrary, increased in animals exposed to cold for 24 hr. Propranolol did not modify the mentioned changes brought about by immobilization or exposure to cold.
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PMID:The hypothalamic and neurohypophysial oxytocic activities in stressed rats: independence from beta-adrenergic blockade. 654 94

Rats dehydrated up to 12 days were given intraperitoneally propranolol hydrochloride in daily dose of 1.0 mg/100 g of initial body weight. In not dehydrated animals the only dose of propranolol increased significantly the vasopressin and oxytocin release from the neurohypophysis. In dehydrated animals propranolol restrained somewhat the decrease of vasopressin in the neurohypophysis, but intensified the vasopressin depletion in the hypothalamus. The oxytocic potency of both the neurohypophysis and hypothalamus decreased progressively in animals deprived of water. Propranolol potentiated this effect of osmoreceptor stimulation.
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PMID:The hypothalamic and neurohypophysial vasopressor and oxytocic activities as influenced by beta-adrenergic blockade during long-term dehydration in the white male rat. 737 5

The influence of propranolol, isoprenaline, papaverine and caffeine on basal tone and contractile responses to spasmogens (oxytocin, KCl) was investigated in the presence and the absence of external calcium in estrogen-treated rat uterus. Isoprenaline, papaverine and caffeine relaxed precontracted uterus and caffeine also decreased the basal tone of uterine muscle in calcium-containing or calcium-free solution. Propranolol had a dual activity in calcium-free medium: lower concentrations contracted the sustained contraction elicited by oxytocin, whereas the highest concentration partially relaxed it. In calcium-containing solution the highest dose of propranolol partially inhibited KCl-induced contractions.
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PMID:Different actions of some relaxant agents acting via the cAMP system in rat uterus. 762 19

Labour was induced with propranolol and oxytocin in 60 female patients with prolonged pregnancy. An outcome was favourable in 88%. No effect of propranolol on fetal pulse rate and general maternal state was seen. Propranolol shortened I phase of labour by approximately 30% in primigravidae.
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PMID:[Induction of labor in prolonged pregnancy with propranolol as a personal evaluation]. 808 19


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