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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Depolarization of the neuronal membrane in the snail neurons induced by oxytocin application to the soma of these neurons have been examined under voltage clamp conditions. Replacement of external chloride by HEPES led to an increase its amplitude and a shift of its current-voltage characteristic in the depolarizing direction. External application of furosemide inhibited the current evoked by oxytocin application. Extracellular application of theophylline increased its amplitude. Imidazole, tolbutamide and temperature decrease had an opposite effect on this current. It is suggested that the surface membrane of some snail neurons probably possesses oxytocin receptors whose activation leads to the increase of its chloride permeability. This process is probably mediated through the system of cyclic nucleotides.
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PMID:[Effect of application of oxytocin on neurons of Helix pomatia: depolarization effects]. 321 Dec 30

Imidazole (3.67 x 10(-3) M) and sodium bicarbonate (1.78 x 10(-2) M) failed to alter acetylcholine evoked responses in isolated rat uterus but they produced a significant shift of the log dose-response curve of oxytocin to the left. This potentiating effect was reversible. Addition of imidazole increased the pH of de Jalon solution from 7.2 to 8.5. Sodium dihydrogen orthophosphate (3.3 x 10(-3) M) prevented the change of pH due to the addition of imidazole and at the same time the potentiating effect of imidazole was inhibited. The present study strongly suggests that the potentiation of oxytocin-evoked responses by imidazole is due to the change in pH of de Jalon solution towards more alkaline range and it may not be due to stimulation of phosphodiesterase activity of rat uterus.
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PMID:Effect of imidazole on oxytocin and acetylcholine induced responses in isolated rat uterus: with observations on its mechanism of action. 743 34

Adrenomedullin 2/intermedin (AM2/IMD) is a new member of the calcitonin/calcitonin gene-related peptide (CGRP) family. CGRP, adrenomedullin (AM), and AM2/IMD share the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP). The CRLR/RAMP2 or CRLR/RAMP3 complex forms the AM receptor, whereas the CRLR/RAMP1 forms the CGRP receptor. AM2/IMD binds non-selectively to all three CRLR/RAMP complexes. AM2/IMD has various actions, such as a potent vasodilator action and a protective action against oxidative stress, like AM and CGRP. When administered intracerebroventricularly, AM2/IMD stimulates the sympathetic nervous system and increases blood pressure. In human hypothalamus, AM2/IMD is expressed in the paraventricular and supraoptic nuclei and colocalized with arginine vasopressin. Anterior pituitary cells were diffusely immunostained for AM2/IMD. AM2/IMD stimulates the release of ACTH, prolactin, and oxytocin, but suppresses GH release. Some of these pituitary actions of AM2/IMD have been supposed to be mediated by an unidentified unique receptor for AM2/IMD. In the adrenal gland, immunoreactive (IR)-AM2/IMD and IR-AM were detected in the medulla, while the degree of IR-AM2/IMD and IR-AM in the cortex was relatively weak or undetectable. Furthermore, AM2/IMD and AM were expressed in adrenocortical tumors, such as aldosterone-secreting adenomas, and pheochromocytomas. CRLR and RAMPs are expressed in the hypothalamus, pituitaries, adrenal glands, and adrenal tumors. Thus, AM2/IMD is expressed in every endocrine organ of the hypothalamo-pituitary-adrenal axis together with its receptor. AM2/IMD may act as a neurotransmitter or modulator in the brain and as a paracrine/autocrine regulator in the hypothalamo-pituitary-adrenal axis.
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PMID:Adrenomedullin 2/intermedin in the hypothalamo-pituitary-adrenal axis. 2059 93