Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dehydroepiandrosterone sulfate (DHAS) has been shown to promote cervical ripening. We have investigated the effect of DHAS administration on the onset of spontaneous labor and delivery in 92 normal primiparous patients. We also investigated the effect of DHAS administration on the induction of labor with oxytocin at term in 47 normal primiparous patients. Twice weekly administration of 200 mg-DHAS intravenously to primiparous patients beginning at the 37th week of gestation resulted in earlier onset of spontaneous labor than once weekly administration. In patients in whom labor was induced at term with intravenous oxytocin, pretreatment with DHAS (200 mg intravenously) resulted in a shorter induction interval than in patients not given such pretreatment. We conclude that DHAS given systemically accelerates the onset of labor and endogenous DHAS may play a role in the mechanism of labor.
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PMID:Dehydroepiandrosterone sulfate and induction of labor. 252 9

In the present study, we have examined the steroid hormone effect on oxytocin receptor (OTR) expression in human myometrial monolayer culture. The myometrial cells were cultured for 24-72 hours in serum-free media with various concentrations of steroid hormones. The plasma membrane of the cultured cells was then collected. The 125I-oxytocin(OT) was employed for a binding assay and the mean binding and dissociation constant were evaluated by Scatchard analysis. 1. The OT binding values in the presence of estradiol free, 10(-8) M, and 10(-7) M at 72 hours were 19.85, 28.12, and 36.20pM/mg protein, respectively. 2. The OT binding values in the presence of estradiol (10(-7) M) at 24, 48, and 72 hours were 17.85, 23.72, and 36.20pM/mg protein, respectively. 3. Dehydroepiandrosterone sulfate (10(-5) M) exerted almost no effect on the OTR expression by estradiol (10(-7) M). Cortisol (10(-5) M) decreased the amount of OTR expressed by estradiol. 4. The changes in OTR expression caused by estradiol (10(-7) M) were inhibited according to the concentration by progesterone. The concentration of progesterone at which OT binding was reduced 50% was 2.7 x 10(-6) M (E/P ratio = 0.037). These results suggested that estradiol increased the amount of OTR discovered in human myometrial cells in a time and concentration dependent manner, while progesterone inhibited the changes in OTR expression by estradiol in a concentration dependent manner. Thus, it was indicated that the changes in the E/P ratio during pregnancy which regulate the OTR expression control the myometrial contraction.
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PMID:[The effect of steroid hormone on oxytocin receptor expression in primary human uterine myometrial cell culture]. 839 13