Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of the selective beta-2-receptor stimulator terbutaline on the activity of gravid, human myometrium were investigated in vitro and in vivo, before and after administration of different beta-receptor blockers. Terbutaline, 0.2-1.0 mu-g/ml, inhibited the spontaneous contractile activity of isolated strips of myometrium. This effect was unaffected by the selective beta-a-receptor blockers practolol, 1 mu-g/ml, and H 93/26, 1 mu-g/ml. However, the non-selective blocker propranolol, 0.1 mu-g/ml, completely inhibited the terbutaline effects. The in vitro effects of terbutaline could be correlated with findings in vivo. Intra-uterine pressure was recorded in 4 pregnant women at term. Infusion of terbutaline, 10-15 mu-g/min, for 20-40 min, effectively inhibited both spontaneous and oxytocin-stimulated uterine activity. There was a moderate increase in maternal heart rate, but no consistent effect on maternal blood pressure. Fetal heart rate was little affected. The uterine effects of terbuline were not influenced by practolol, 5-20 mg i.v., but completely inhibited by propranolol, 1-2 mg i.v. The results suggest that terbutaline inhibits uterine motility by effects on uterine beta-2-receptors and that it can be given in clinically effective doses without adverse circulatory effects on mother or fetus.
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PMID:Effects of terbutaline on human uterine motility at term. 113 22

Fifty patients were compared for the purpose of investigating the usefulness of intrauterine resuscitation with tocolysis (IURT). Terbutaline was given, as an intravenous bolus, to 31 women in labor in whom fetal distress was diagnosed and urgent delivery by cesarean section was indicated. In alternate months, a control group of 19 women with similar diagnoses was urgently delivered after standard interventions such as maternal positioning, oxygen administration, hydration, and discontinuation of oxytocin. Improvement in perinatal outcome was shown in infants after IURT. Apgar scores were less than 7 in 42% of the study group and in 71% of the control group at 1 minute (P = .04). Five-minute Apgar scores less than 7 occurred in 7% of the study group and 24% of the control group. A low venous pH was seen in 55% of the control group compared with 29% of the infants resuscitated with terbutaline. Estimated maternal blood loss and hematocrit change was not different in the two groups. Maternal blood pressure and pulse changes following IURT were modest and of doubtful significance. We conclude that intravenous terbutaline administered as a bolus injection at the time of fetal distress in labor improves infant outcome as evidenced by more vigorous Apgar scores and less acidemia without significant adverse physiologic effects on the mother.
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PMID:Intrauterine resuscitation with tocolysis. An alternate month clinical trial. 268 80

The effects of prostacyclin (PGI2) on the uterine muscle of pregnant rats were studied in terms of uterine contraction and the variation in cyclic nucleotides. The following results were obtained: The administration of PGI2 stimulated the pregnant uterine muscle (in vitro). The oxytocic potency of PGE1-analog (ONO-802) was greatest, followed in order by that of PGF2 alpha and PGI2. The effect of 5-lypoxygenase inhibitor (AA-861) on uterine contraction was greatest under the administration of LTC4, followed in order by PGI2, oxytocin, PGF2 alpha, LTD4 and ONO-802. The effect of AA-861 was greater under the simultaneous administration of LTD4/LTC4 and ONO-802 than under the simultaneous administration of oxytocin and ONO-802. Terbutaline exerted the inhibitory effect on each of the oxytocies within two minutes in all cases. Its inhibitory effect on the oxytocics was slight in the cases to which oxytocin or ONO-802 was administered. Changes in cyclic nucleotides in the bath medium were determined before and after the administration of each drug. When PGI2 was administered, both c-AMP and c-GMP increased and showed a pattern which was different from that for other oxytocics. This tendency was also observed when PGI2 and other drugs (terbutaline, ONO-802 and AA-861) were administered together.
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PMID:[A basic study of the oxytocic effect of prostacyclin on the uterine muscle in pregnant rats]. 353 66

The effect of terbutaline sulfate on left ventricular size and performance was studied by M-mode echocardiography in pregnant women with premature labor. Patients with uterine activity initiated during either oxytocin challenge testing or induction of labor served as a comparison group. During terbutaline therapy, heart rate, ejection fraction, and cardiac output increased significantly. End-diastolic volume and systolic blood pressure (BP) were unchanged, and diastolic BP and end-systolic volume fell. No changes in echocardiographic or hemodynamic parameters were present during oxytocin-induced uterine activity. Terbutaline, as currently used to prevent premature labor, is a potent inotropic and chronotropic agent. Pulmonary edema accompanying terbutaline treatment is probably not due to cardiac failure.
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PMID:Terbutaline and maternal cardiac function. 731 Sep 63