Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the present study the fine structure of rat Leydig cells was examined by electron microscopy.
Oxytocin
and dexamethasone induced changes in the activities of 3beta hydroxysteroid dehydrogenase,
NADH2
cytochrome-C-reductase and glucose-6-phosphate dehydrogenase in these cells were studied in an in vivo experiment. Two groups of male Wistar rats were used to test the effects of
oxytocin
--rats from group I received a single injection of
oxytocin
; rats from group II were given a 10-day course of
oxytocin
. Pregnant female rats were injected with dexamethasone on day 17 and 18 post conception. The testes of 19 and 20-day old embryos were removed. It was established that both short and long term courses of
oxytocin
increased the activities of the above-mentioned enzymes. On the contrary, prenatal administration of dexamethasone decreased enzymatic activity in Leydig cells. Electron microscopy revealed clusters of fetal Leydig cells. Our results indicated the role of
oxytocin
in the local regulation of steroidogenesis and the importance of glucocorticoids in the differentiation and activity of Leydig cells.
...
PMID:Dexamethasone and oxytocin effects on rat Leydig cells--morphological and enzyme-histochemical characteristics. 1258 May 30
