Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The immunohistochemical localization of CRF- and neurophysin-containing neurons in the hypothalamus of the Mongolian gerbil was studied by means of the PAP technique. The CRF-immunoreactive fibers were detected mainly in the outer layer of the median eminence of intact adult male gerbils. The CRF-positive neurons respond to aminoglutethimide (Elipten, Ciba) administration by showing increased immunoreactivity and an increase in the number of stained cell bodies in the parvocellular division of the paraventricular nucleus. Aminoglutethimide treatment results also in an increase in the number of neurophysin-immunoreactive nervous fibers localized in the internal layer of the median eminence. However, CRF-immunoreactive fibers are observed mainly in the outer layer of the median eminence while neurophysin-immunopositive axons are seen predominantly in the internal layer of this region. Since the axons of paraventricular neurons run to the median eminence and their staining ability is changed due to aminoglutethimide, their involvement in the endocrine control of hypophysial ACTH release is postulated.
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PMID:Studies on hypothalamo-pituitary corticoliberin system. I. Localization of corticotropin-releasing factor (CRF)- and neurophysin-immunoreactive neurons in the Mongolian gerbil (Meriones unguiculatus). 303 37

Experiments were performed with cultured bovine granulosa cells to examine the relationship between the secretions of oxytocin and progesterone and to determine whether progesterone could be responsible for the progressive refractoriness of these cells to stimulation by ascorbic acid. Aminoglutethimide suppressed progesterone secretion by 95% but it neither reduced oxytocin secretion nor restored the cellular response to delayed ascorbate treatment. Addition of a high concentration of progesterone to the culture medium also failed to affect oxytocin secretion, its stimulation by ascorbate, or the endogenous secretion of the steroid. It is concluded that oxytocin and progesterone can be independently secreted and that progesterone regulates neither its own secretion nor that of oxytocin.
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PMID:Ovarian oxytocin and progesterone are secreted independently of one another. 337 42