Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The synthetic 1-beta,beta-disubstituted analogues of [1-deamino]-oxytocin, [1'-(1'-thio-4'-methylcyclohexane)-acetic acid 1]-oxytocin (MeCAOT) a peripheral oxytocin antagonist, and [1'-(1'-methyl-4'-thiopiperidine)-acetic acid 1]-oxytocin (MePAOT), devoid of peripheral anti-oxytocin activity, were found to improve social memory of rats. The social memory in rats was disrupted by a wide range of doses of oxytocin (6-750 mU/kg) and this amnestic effect of oxytocin was antagonised by MePAOT and MeCAOT.
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PMID:Opposite action of oxytocin and its peptide antagonists on social memory in rats. 204 86

Two new 1-beta,beta-disubstituted analogues of [1-deamino]-oxytocin dOT: [1'-(1'-thio-4'-methylcyclohexane)-acetic acid1]-oxytocin (MeCAOT), and [1'-(1'-methyl-4'-thiopiperidine)-acetic acid1]-oxytocin (MePAOT), were synthesized to determine some of the structural features that account for antioxytocic potency. The protected precursors required for these analogues were synthesized by a combination of solid phase and 8 + 1 couplings in solution. MeCAOT is an effective antagonist of oxytocic response to oxytocin (pA2 = 7.3).
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PMID:Synthesis and some pharmacological properties of two new antagonists of oxytocin. 343 12