Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficieny of 2 methods utilized for midterm abortion in teenagers were reviewed. The review covered 240 cases of abortion admitted to Patna Medical College, Patna, India over th 1977-82 period. The patients range in age from 13-29 years and duration of pregnancy varied from 14-22 weeks. In group A, made up of 120 cases, an autoclaved rubber catheter was introduced in the extraamniotic space through the cervical canal. The mode of treatment in group B, which also comprised 120 cases, was instillation of 20% saline through the cervical canal with the help of a No. 18 spinal needle in the intraamniotic space. To accelerate the abortion process, intravenous drip of 2.5 units oxytocin added in 5% dextrose was given routinely in both groups. The rate of infustion was 30 drops/minute. If abortion was not completed by 72 hours, it was considered as a failed case. The uterine contractions started after 2 hours of the introduction of the catheter in 10% of the cases. Taking up of the cervix occurred satisfactorily in catheter group, but the same was not the case in the saline group. Though the inducation abortion interval was comparable in both groups, the complication rate was high in group B. The patients were more apprehensive in group B as compared to group A. The success rate was 93.3% in group A and 83.3% in group B. The use of the extraamniotic rubber catheter is one of the safest, most economical, and efficacious modes of abortion of midtrimester pregnancy in mulliparous unmarried teenagers.
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PMID:Mid-trimester pregnancy termination in teenage women. 400 60

The efficiency of oxytocic drugs in therapeutic abortion was studied in 113 women who were randomly assigned to either a control group (n = 44) receiving no oxytocic drugs, a group (n = 36) receiving 0.2 mg ergometrine by slow intravenous injection, or a group (n = 33) given 5 units oxytocin in a intravenous infusion throughout the procedure. The three groups were comparable with regard to the age of patients, the age of pregnancies and parity. The surgical procedure was the same in all three groups and carried out by the same surgeon. General anaesthesia was obtained with an infusion of 500 mg methohexitone and 500 micrograms fentanyl in 500 ml isotonic dextrose solution at a rate of 3 ml X min-1. The anaesthetic requirements were 2.94 +/- 0.80 micrograms X kg-1 fentanyl and 2.94 +/- 0,80 mg X kg-1 methohexitone. The criteria studied were the blood loss as measured by the volume aspired, the presence or absence of nausea and vomiting after the procedure, the age of pregnancy and the total amount of anaesthetic drugs given. No correlation was found between the amount of anaesthetic drugs given and the frequency of nausea and vomiting, and between the amount of blood lost (r = 0.287; ddl = 111; alpha = 17.322). The study did not, therefore, confirm the reputation of oxytocic drugs in reducing the bleeding. It seemed that, in therapeutic abortion, spontaneous uterine contraction was sufficient to control the bleeding. But a significant correlation was found between the amount of blood lost and the age of the pregnancy (r = 0.399; ddl = 111; alpha less than 1%).
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PMID:[Blood loss and nausea during legal abortion]. 401 96

53 patients undergoing second trimester saline abortion were given either 20 units or 100 units of oxytocin per 500 ml of 5% dextrose solution 12 hours after saline instillation. Mean abortion time (30.67 hours, 20 units; 27.66 hours, 100 units) was 11-14 hours less than a control group of 26 patients who did not receive oxytocin (41.26 hours). The smaller dose is as effective as the larger dose and should prove safer for patients undergoing saline abortion.
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PMID:Oxytocin augmentation of saline abortion. 469 79

This study combined the use of preinjection laminaria, intravenous oxytocin, and 15 mg of intra-amniotic prostaglandin (PG) F2alpha in order to demonstrate a potentially improved procedure for 2nd trimester abortion. 20 patients, aged 18-27, were between the 16-20 weeks gestation, and were free of intercurrent medical or obstetrical problems. 7 of the 20 were nulliparae. A laminaria was inserted into the cervix the evening before the injection of PG. In the morning an intravenous infusion was begun using 50 units of oxytocin in 500 ml of 5% dextrose and 0.9% sodium choloride at a rate of 150 ml/hour. The amniocentesis was performed and when a free flow of clear amniotic fluid was obtained 15 mg. of PGF2alpha was injected into the amniotic cavity. Different concentrations of oxytocin were administered if contractions were increasingly painful or not. Results of the experiment were that: 1) all patients aborted within 24 hours of the prostaglandin injection, 2) the median injection-to-abortion interval was 7 hours and 25 minutes; primigravidae aborted with a median time of 15 hours 20 minutes; and multiparous patients aborted in 6 hours 20 minutes; 3) only 9 patients requested analgesia medication; 4) the average blood loss was 150-200 nl; 1 patient had a postabortion hemorrhage greater than 500 ml; 5) 3 patients underwent sharp curettage for suspected retained secundines; 6) vomiting occurred in 6 patients, 3 of whom had emesis once; and 7) no diarrhea was encountered during the study. This study demonstrates that this procedure fulfills 3 strict criteria for success, as follows: 1) single injection technic, 2) consistent abortion within 24 hours, and 3) minimal side effects.
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PMID:Midtrimester abortion using prostaglandin F2alpha, oxytocin, and laminaria. 471 13

Laminaria tents were used in addition to the technique of saline abortion in an attempt to shorten the injection-abortion interval. 142 second trimester therapeutic abortion patients, aged 13 to 40 years, agreed to participate in the study and were assigned to 1 of 4 groups. 72.2% were single, 27.8% were married, and the gestational age was from 13 to 20 weeks. Group 1 (26 primigravid patients) served as the control group (no oxytocin or laminaria tent used). Group 2 (25 primigravid patients) received an intravenous infusion of 20 units oxytocin/500 ml of 5% dextrose in water (beginning 12 hours after saline injection). Group 3 (50 primigravid patients) likewise received an infusion of 20 units oxytocin/500 ml of 5% dextrose in water (beginning 12 hours after saline injection), and in addition, a single medium, sterile laminaria tent was inserted at the time of the saline injection and removed 12 hours after insertion. Group 4 (41 multigravid patients) received treatment identical to that of Group 3. The mean interval time from injection to delivery in Group 1 was 41.26 hours. The mean injection-abortion time was 30.67 hours for Group 2, 26.84 hours for Group 3, and 22.96 hours for Group 4. The complication rate was significantly higher for both the oxytocin plus saline group (Group 2) as well as the laminaria plus saline groups (Groups 3 and 4). Group 3 experienced a 22% febrile rate, and 18% of patients required uterine curettage, while the figures for Group 4 were 12.2% and 24.4%, respectively. The laminaria tents did result in an 11% to 15% increase in complications in Groups 3 and 4, respectively, as compared with Group 2.
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PMID:Laminaria digitata in saline abortions. 482 61

We studied the effect of oxytocin induction or augmentation of labor on rates of bilirubin production in newborns at three different institutions. Bilirubin production, assessed quantitatively by the pulmonary excretion rate of carbon monoxide or qualitatively by the blood carboxyhemoglobin concentration, was not elevated when compared with appropriately matched control groups. Previous studies have implicated administration of large volumes of electrolyte-free dextrose solutions together with oxytocin as an important factor contributing to hemolysis in the infant. The mothers in our studies received minimal amounts of free water. We conclude that oxytocin induction or augmentation of labor does not result in neonatal hemolysis and subsequent hyperbilirubinemia when it is administered without large volumes of sodium-free intravenous solutions.
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PMID:Oxytocin and neonatal hyperbilirubinemia. Studies of bilirubin production. 649 21

Simulating actual conditions of intravenous infusion, a number of routinely used additive drugs were tested for potential binding to an inline i.v. filter containing a cellulose ester membrane. Two infusion solutions, 5% dextrose and 0.9% sodium chloride, were used to deliver the drugs. Drug samples were assayed before and after passage through the filter by the following methods: bleomycin sulfate, cyanocobalamin, ergonovine maleate, mithramycin, vinblastine sulfate, and vincristine sulfate by direct spectrophotometry; oxytocin by biological assay; levarterenol by fluorescence; and folic acid, heparin, insulin, and digitoxin by radiotracer methods. Measurable reduction in potency occurred in both infusion solutions with digitoxin, insulin, mithramycin, and vincristine sulfate. No reduction in potency was observed in either infusion solution with bleomycin sulfate, cyanocobalamin, ergonovine maleate, folic acid, heparin, leverterenol bitartrate, oxytocin, and vinblastine sulfate. The study results indicate that the potency of drugs administered intravenously in small doses could be significantly reduced during inline filtration through a filter containing a cellulose ester membrane.
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PMID:Effect of inline filtration on the potency of low-dose drugs. 739 87

A retrospective study was made of the relation between the cord serum sodium levels and the intravenous administration to the mother of 5 per cent dextrose and oxytocin. Of the 203 mothers studied, 106 received intravenous fluid before delivery. The mean sodium levels of babies of mothers who had intravenous fluid (133 +/- 4.2 (SD) mkmol/l) was significantly lower than for babies of mothers who had not (138 +/- 4.3 (SD) mmol/l).
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PMID:The relation between cord serum sodium levels in newborn infants and maternal intravenous therapy during labour. 739 86

We performed a prospective randomised study on one hundred primigravid women who required oxytocin to augment labour, comparing dextrose infusion with normal saline. After delivery, the 45 patients whose oxytocin was infused in dextrose had significantly lower serum sodium levels in both mother and baby compared to the 48 patients who had their oxytocin administered in normal saline. This was particularly evident in those cases where epidural analgesia was employed.
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PMID:Hyponatraemia and non-electrolyte solutions in labouring primigravida. 765 8

HIT-T15 cells prelabeled with [3H]-arachidonate were incubated for 15 minutes at 37 degrees C in Krebs Ringer buffer (pH 7.1) in the presence and absence of various agonists. Radioactivity remaining in major phospholipids was measured at the end of incubation period. Oxytocin (1 microM), vasopressin (1 microM), and A23187 (5 microM) stimulated loss of radioactivity from phosphatidylinositol and phosphatidylcholine. No loss of radioactivity from either of the phospholipids, however, was detected in the presence of 10 mM D-glucose, an insulin secretagogue in HIT-T15 cells. The lack of phosphatidylinositol response to glucose was also evident when the cells were prelabeled with myo-[3H] inositol. The formation of inositol phosphates at 15 minutes was readily observed upon the treatment of myo-[3H] inositol-labeled cells with oxytocin or vasopressin but not glucose or A23187. Inability of glucose to stimulate phosphatidylinositol and phosphatidylcholine hydrolysis in beta cell-derived HIT-T15 cells contrasts sharply with results from studies with pancreatic islets, where hydrolysis of these two phospholipids is readily observed and thought to contribute to the signaling mechanism responsible for stimulation of insulin secretion.
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PMID:Vasopressin and oxytocin but not glucose stimulate hydrolysis of phosphatidylinositol and phosphatidylcholine in a hamster insulinoma. 841 74


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