Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of smoking on a fetus include higher perinatal mortality rates, lower birth weight, and impaired mental and physical growth due to carbon monoxide and nicotine. Infants of smoking mothers have greater risk for uteroplacental insufficiency which can be detected by the RAD (fetal activity-acceleration determination). A study of 350 high-risk nonsmoking pregnant women and 128 smoking pregnant women showed that pre-eclampsia was significantly less in smoking women; however, there was a higher incidence of fetal nonactivity (20.8% versus 13.1% for nonsmokers). When nonreactive FAD was evaluated, and OCT (oxytocin challenge test) was performed with more positive OCT's encountered in the nonsmoking group. Cesarean sections were higher (21.9%) in smokers than nonsmokers (17.8%) and cesareans due to fetal distress were also higher in smokers (3.9%). There was a 254.1 gm mean birth weight difference for infants of smoking mothers. Sporatic progression from reactive to nonreactive FAD may be due to: 1) a mother smoking prior to an FAD which could stimulate activity; or 2) exhaustion in the morning after the fetus has been stimulated due to smoking for approximately 16 hours; therefore, depending on when the last cigarette was smoked, fetal reactivity or nonreactivity could result.
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PMID:Diminished fetal reactivity with smoking. 735 4