Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The infusion of beta-adrenomimetic drug (bamethan sulphate--BS) on day 11 of the oestrous cycle markedly increased peripheral progesterone concentration whereas infusion of beta-antagonist (propranolol) decreased plasma progesterone levels in heifers. Oxytocin injected on days 2-6 of the oestrous cycle shortened the length of the cycle (to 7-9 days) whereas the length of the cycle in heifers injected with oxytocin followed by injections of either BS or xanthinol (theophylline nicotinate--a potent vasodilatory drug) was normal (21.8 +/- 1.7). Heifers injected with BS on days 13-21 of the oestrous cycle had increased levels of progesterone on days 13-19 of the cycle and the length of the cycle was normal (22.3 +/- 0.6 compared with 21.3 +/- 1.5 for the control). The data indicate that: (1) beta-adrenergic stimulation overcomes the action of oxytocin given on days 2-6 of the cycle, whereas the stimulation of beta-receptors on days 13-21 of the oestrous cycle raised progesterone plasma concentration but did not prevent spontaneous luteolysis. (2) Basal secretion of progesterone in cattle is partly dependent on constant beta-adrenergic stimulation.
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PMID:Involvement of beta-adrenoceptors in the regulation of luteal function in cattle. 165 46

Noradrenaline stimulates the concomitant release of ovarian oxytocin and progesterone in cattle within a few minutes, but the mechanism of its action is unknown. Changes in alpha- and beta-receptors and blood pressure were considered as possible mechanisms of the noradrenaline effect. Heifers in group 1 (n = 4) were infused with noradrenaline (0.16 microgram kg-1 min-1) for 30 min into the aorta abdominalis (cranial to the origin of the ovarian artery) on day 10. On days 11 and 12 before noradrenaline, phentolamine (alpha-blocker; 30 micrograms kg-1 min-1) or propranolol (beta-blocker; 5 micrograms kg-1 min-1) were infused for 30 min. Four other heifers were infused with noradrenaline only as controls. Only propranolol inhibited the stimulatory effect of noradrenaline on the secretion of progesterone and oxytocin. In group 2, heifers (n = 4) were infused, making use of the latin square design, with vasoconstrictive (angiotensin; 0.042 microgram kg-1 min-1) or vasodilatory (xanthinol-theophylline nicotinate; 250 micrograms kg-1 min-1) drugs that do not act through the adrenoceptors. Noradrenaline (0.3 microgram kg-1 min-1) was given 1 h later as in group 1. Blood pressure changes were measured in the posterior aorta abdominalis and oxytocin and progesterone concentrations were determined in the blood samples collected from the jugular vein. Noradrenaline and angiotensin increased (P < 0.01), whereas xanthinol decreased (P < 0.01), blood pressure during their infusion. However, the rise of oxytocin and progesterone concentrations was observed only after noradrenaline infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Mechanism of noradrenaline influence on the secretion of ovarian oxytocin and progesterone in conscious cattle. 838 56