Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam. Diazoxide precipitously decreased both systolic and diastolic blood pressure proportionately (35-50%); the nadir was invariably reached in 5-15 minutes. Diastolic pressure never fell below 50 torr, and mean arterial pressure always exceeded 70 torr. Oliguria was not apparent. The vasodepressor response was fairly persistent for 4 hours in all but 3 patients; 2 of these received a second 300-mg dose. Significant changes in fetal heart activity (bradycardia, dysrhythmia) were observed in only 1 patient. Labor was immediately ablated in all patients, but could be restimulated with oxytocin. All pregnancies were terminated within 7 hours (mean, 3.7 hours), seven of them by cesarean section. Eleven newborns did well. We conclude that the immediate reduction in maternal arterial blood pressure is without apparent hazard to the mother as well as the fetus.
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PMID:The management of severe preeclampsia and eclampsia with intravenous diazoxide. 86 30

Physiological role and importance of calcium ion has been investigated based on the study of the mechanism of muscle contraction. Furthermore, calcium ion has been proved to have a wide variety of biological roles in hormonal secretion, cell proliferation and reproduction as well as in muscle contraction. In this lecture, I would like to show a method to measure intracellular calcium ion concentrations ([Ca2+]i) and to give a general information about the roles of calcium ion to induce various cell activities. Then I would like to talk about the changes in intracellular calcium concentration ([Ca2+]i) and their meaning in the field of reproductive physiology including uterine muscle contraction, pituitary LH secretion, and fertilization. 1) Uterine muscle contraction and calcium ion The function of calcium ion is most intensively investigated in muscle contraction. We show [Ca2+]i increase in cultured myometrial cells. This increase is inhibited by omission of extracellular calcium or addition of calcium channel blockers. These results support usefulness of Ca2+ channel blockers in treating threatened premature delivery. We also report the action of MgSO4 as an inhibitory agent of [Ca2+]i increase stimulated by oxytocin. 2) Pituitary gonadotropin secretion and calcium ion Pituitary LH secretion is regulated by gonadotropin releasing hormone (GnRH). GnRH induces rapid increases and then sustained releases of LH secretion. By the omission of extracellular calcium, or by addition of Ca2+ channel blockers, the sustained phase of LH secretion is abolished. GnRH also increase [Ca2+]i in a very similar manner to that of LH secretion. The [Ca2+]i increase is essential in LH secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Roles of calcium ion in reproductive physiology]. 140 28

A retrospective review identified 56 patients with uterine inversion, from July 1977 through June 1986, from weekly obstetric statistics, delivery records and computerized discharge diagnoses. All patients underwent delivery by house officers, midwives or medical students under supervision. An analysis of the data revealed that the risk factors were primiparity, a fundally implanted placenta and delivery of a macrosomic fetus. Also, patients who received oxytocin with or without MgSO4 were at higher risk of puerperal inversion. MgSO4 by itself did not appear to be a risk factor. A placenta attached at the time of inversion appeared to have a protective effect against the development of shock. The use of betamimetics or MgSO4 appeared to be an acceptable alternative to general anesthesia in relaxing the uterus and aiding in its repositioning. Those agents were more likely to be successful in acute cases than in subacute ones and in second-degree inversion than in third-degree.
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PMID:Acute puerperal uterine inversion. New approaches to management. 292 34

From 1978 to 1982, 70 cases of emergency hysterectomy for obstetric hemorrhage were performed at Los Angeles County/University of Southern California Women's Hospital. Sixty hysterectomies followed cesarean section, and ten were performed for hemorrhage after vaginal delivery. The most common indication for hysterectomy was atony (43%) followed by placenta accreta (30%), uterine rupture (13%), extension of a low transverse incision (10%), and leiomyomata preventing uterine closure and hemostasis (4%). Hysterectomies performed for atony had a significant association with the following factors when compared to hysterectomies performed for other indications: 1) amnionitis, 2) cesarean section for labor arrest, 3) oxytocin augmentation of labor, 4) MgSO4 infusion, and 5) fetal weight. Fifty-seven percent of hysterectomies performed for placenta accreta were associated with a previous cesarean section. During the study period, 53% of all patients presenting at term with both a placenta previa and one or more previous cesarean sections, subsequently underwent hysterectomy for placenta accreta. Even with a broad inclusion of risk factors, only 74% of patients developing a hemorrhagic complication leading to hysterectomy can be identified before delivery.
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PMID:Emergency hysterectomy for obstetric hemorrhage. 646 67