Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The changes of
oxytocin
content and mRNA expression in some nuclei were investigated in morphine-dependent rats using radioimmunoassay (RIA) and in situ hybridization (ISH). After chronic administration of morphine, the
oxytocin
content in supraoptic nucleus (SON) and nucleus accumbens (NAc) decreased, and increased in the ventral tegment area (VTA) and locus coeruleus (LC), but did not change in other nuclei including the paraventricular nucleus (PVN), lateral septum (SEPTUM), raphe magnus nucleus (
NRM
) and periaquaductal gray (PAG). In morphine-L dependent rats, naloxone increased the levels of
oxytocin
in SON and PVN, but decreased that in LC. ISH first showed that chronic morphine treatment inhibited the
oxytocin
synthesis in SON but not in PVN. The present study demonstrates that chronic morphine treatment alters the brain
oxytocin
system, suggesting that
oxytocin
might contribute to the behavioral and neuroendocrine responses to morphine.
...
PMID:Chronic morphine treatment inhibits oxytocin synthesis in rats. 1104 33
