Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Subcellar localization of ionic Ca was investigated by the Pb-acetate cytochemical method in rat myometrium on the 21st day of pregnancy, following oxytocin and Bricanyl treatment. Following Oxytocin treatment the amount of ionic Ca increased in the muscle cells of the uterus and decreased in the plasma membrane and mitochondria as compared with the control. Tocolytics given in the last four days of pregnancy caused a decrease in the cytoplasmic concentration of ionic Ca and increased the Ca++ content of Ca++ pools (plasma membrane, mitochondrium). The change in the intracellular distribution of Ca++ may be involved in the mechanism of action of tocolytics and in the development of the relaxation of smooth muscle.
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PMID:Contributions to the mechanism of action of beta-adrenergic stimulants. 647 23

Our study concentrated upon the modifications of some parameters which characterize uterine smooth muscle contractile activity under the action of active substances. We studied the isotonic contractions of the uterine smooth muscle in a classical organ bath in which we introduced some contracting and relaxing substances. At the beginning, we introduced Oxytocin to determine uterine smooth muscle contractions. After that, we added relaxing substances (Papaverin, Diazepam, Terbutalin, Isoxuprin, Hexoprenalin) in the organ bath, and then, in another protocol, we added combinations of two relaxing substances. We determined for each wave some parameters: minimum, mean, maximum and net amplitude, wave area and duration, the interval between waves, the time while the curve increases from the minimal value of the amplitude to the maximum value, the frequency of contractile waves. For each parameter we determined the variance coefficient (C.V. %), which reflects the regularity of the uterine activity. We observed a regularizing effect of the uterine activity after administration of some active substances. The smallest variance coefficient (C.V. %) was found for HEXO + PAP combination (mean value for C.V. % is 4.71%).
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PMID:The regularizing effect of some active substances upon uterine smooth muscle contractile activity. 1106 7