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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The uterine contraction patterns and the changes in fetal heart rate (FHR) were studied in cardiotocographic recordings from 26 women in oxytocin-induced labour, 26 women in PGF2alpha-induced labour and 24 women during the later part of spontaneous labour. The contraction patterns and their effect on the FHR did not differ between the three groups. During the course of labour an increasing steepness of the upward slope of the contraction wave with increasing intensity of the contraction was found. High frequency of atypical contraction patterns, suggesting some degree of uterine incoordination was found during the active phase of labour in 10 patients, 8 of whom were primiparae. This incoordination could not be related to the effect of induction with either drug. Incoordinated contractions were associated with longer duration of labour and a tendency to more pronounced acidosis in the infant at birth, although mean values still fell in the normal range. Ominous FHR patterns were only seen in 2 cases of uterine hyperactivity during induction of labour.
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PMID:A comparative study of uterine activity in labour induced with prostaglandin F2alpha or oxytocin and in spontaneous labour. I. Pattern of the uterine contractions. 99 76

Serial determination of fetal and maternal pH, Pco2 and BDECF was performed in 34 cases of labour inductions with intravenously administered prostaglandin F2alpha or oxytocin. These values were compared with those found in ten cases of spontaneous labour. With the exception of eight cases of "high risk pregnancies" all the remaining parturients were healthy and within the 38th to 42nd week of gestation. With regard to the cases of "uncomplicated" pregnancies the general patterns of the acid-base changes were very similar in the three groups. The BDECF values in fetal scalp blood, however, showed a more marked tendency to increase in the group induced with prostaglandin. Further analysis of this group revealed that the rise of BDECF values could be attributed to cases with episodes of uterine hypertonus or signs of uterine incoordination. In the "high risk" pregnancy group the pH values in fetal scalp blood were lower and the BDECF values higher than in the group of "normal" pregnancy cases. The general pattern and the magnitude of the acid-base changes do not seem to be influenced by the administration of oxytocin or prostaglandin F2alpha as induction agents providing uterine activity is normal. Abnormal uterine activity, initiated by any of the two induction agents, is, however, associated with an increased risk of fetal acidosis.
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PMID:The induction of labour with prostaglandin F2alpha by intravenous infusion. II. A comparison of fetal and maternal acid-base values with those found in oxytocin induced labour and in spontaneous labour. 453 94