Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The elimination of indocyanin green (IGG) in selected mature newborn babies (n = 50) was investigated on the first postnatal day. The IGG dose was 2 mg/kg body weight. The half time (t1/2), the elimination constant (K2), the dye distribution volume (ml/kg), as well as the level of serum indirect bilirubin on the third postnatal day were measured and calculated. Healthy, mature newborns from spontaneous labor served as controls (n = 14): the two study groups consisted of either growth-retarded (n = 8) or acidotic (n = 8) neonates. According to the management of deliveries, they were spontaneous, assisted by oxytocin drop infusion (n = 10) or under lumbal peridural anaesthesia + oxytocin drop infusion (n = 8). In the acidotic neonates the elimination constant was significantly lower and the half time significantly longer. In the growth retarded newborn babies the difference was not significant. The increase of the level of indirect bilirubin in serum appearing in the acidotic group on the third postnatal day was significantly greater.
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PMID:Effect of oxytocin infusion during labor: indocyanin green elimination and serum bilirubin levels. 401 67

The efficiency of oxytocic drugs in therapeutic abortion was studied in 113 women who were randomly assigned to either a control group (n = 44) receiving no oxytocic drugs, a group (n = 36) receiving 0.2 mg ergometrine by slow intravenous injection, or a group (n = 33) given 5 units oxytocin in a intravenous infusion throughout the procedure. The three groups were comparable with regard to the age of patients, the age of pregnancies and parity. The surgical procedure was the same in all three groups and carried out by the same surgeon. General anaesthesia was obtained with an infusion of 500 mg methohexitone and 500 micrograms fentanyl in 500 ml isotonic dextrose solution at a rate of 3 ml X min-1. The anaesthetic requirements were 2.94 +/- 0.80 micrograms X kg-1 fentanyl and 2.94 +/- 0,80 mg X kg-1 methohexitone. The criteria studied were the blood loss as measured by the volume aspired, the presence or absence of nausea and vomiting after the procedure, the age of pregnancy and the total amount of anaesthetic drugs given. No correlation was found between the amount of anaesthetic drugs given and the frequency of nausea and vomiting, and between the amount of blood lost (r = 0.287; ddl = 111; alpha = 17.322). The study did not, therefore, confirm the reputation of oxytocic drugs in reducing the bleeding. It seemed that, in therapeutic abortion, spontaneous uterine contraction was sufficient to control the bleeding. But a significant correlation was found between the amount of blood lost and the age of the pregnancy (r = 0.399; ddl = 111; alpha less than 1%).
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PMID:[Blood loss and nausea during legal abortion]. 401 96

A case of an allergic reaction to Syntocinon (synthetic oxytocin) administered during Caesarean section is reported.
Anaesthesia 1985 Jul
PMID:Anaphylactoid reaction to oxytocin in pregnancy. 402 68

Experiments were performed to reinvestigate the importance of mammary engorgement for activation of the milk-ejection reflex in the rat. Reflex milk ejection (measured by intramammary pressure recordings during a 2-h suckling test under anaesthesia) was compared in rats with engorged mammary glands (15-h separation from the pups, followed by sham-removal of milk) and in rats with drained mammary glands (15-h separation, followed by milk removal using a foster litter and exogenous oxytocin). In experiment 1, multiple small (2 mu.) doses of oxytocin were used for milk removal: these were effective in emptying the mammary glands and caused no subsequent impairment or change in sensitivity of the mammary response to oxytocin. Using this draining procedure, no significant differences were observed in either the number or relative amplitude of the milk ejections, or the occurrence of pup stretch reactions between engorged and drained rats. Similar results were seen in experiment 2, where an identical draining protocol was used, but the rats were pretreated with propranolol before the suckling test. In experiment 3, large (250 mu.) oxytocin doses were used for milk removal, as in previous studies. Again mammary draining had no effect on milk ejection in a subsequent suckling test (with propranolol pretreatment). However, the number of stretch reactions shown by the pups was significantly (P less than 0.001) reduced from 8.6 +/- 1.4/2 h to 1.9 +/- 0.6/2 h. This effect probably related to long-term impairment of the oxytocin response of the mammary glands following the draining procedure, and could not be attributed to the draining per se.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Reappraisal of the influence of mammary distension on the frequency of milk ejection in the rat. 403 49

The authors report on their experience delivering 87 women vaginally with previous cesarean sections. Epidural anesthesia does not appear to be contraindicated as long as the block is not higher than the level of the tenth thoracic dermatome. The use of an infusion of oxytocin should be accompanied by internal fetal heart monitoring. Furthermore, induction of labor with oxytocic agents appears preferable.
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PMID:[Vaginal delivery after cesarean section: use of peridural analgesia and oxytocics. Apropos of 87 cases with cicatriceal proof]. 405 67

This study examines the efficacy of transabdominal intraamniotic injection of prostaglandins (PGs) in therapeutic abortions. Transabdominal amniocentesis was performed under local anesthesia (1% lignocaine) in 27 patients 14-22 weeks pregnant. Uterine activity was monitored. PGF2alpha 25 mg was given as a single intraamniotic injection in the 1st 14 cases. It was given in 3 doses at 24-hourly intervals for 3 successive days in 1 patient. PGE2 was given in 13 patients, 1 mg initially followed by 2 further 1 mg doses at 10-minute intervals. Intravenous oxytocin infusions were used where necessary, as was hysterotomy. Blood samples were collected in 10 patients before and at 4-6 hourly intervals following PGF2alpha administration until abortion occurred, and in 3 patients 40 hours prior to PG administration. A single 25 mg intraamniotic injection of PGF2alpha successfully terminated pregnancy in only 6 of 14 cases. Average-induction delivery interval was 19.52 hours. 6 other patients necessitated intravenous oxytocin infusions to stimulate effective uterine activity; average induction-abortion interval was 59 hours. 2 patients failed to abort, requiring hysterotomy. 7 of 12 vaginally delivered patients had incomplete abortion. Success rate was higher in PGE2-treated patients, with 11 of 13 patients aborting; average induction-delivery interval was 23 hours and 16 minutes. Side effects experienced included severe abdominal pain (for PGF2alpha), vomiting and mild pyrexia (38 degrees Celsius). No consistant change was observed in plasma steroid concentration until after delivery of fetus and placenta occurred. Transamniotic administration of PGE2 appears effective for therapeutic abortion, but not PGF2alpha.
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PMID:Therapeutic abortion by intraamniotic injection of prostaglandins. 480 68

A prospective study of serum bilirubin levels on the first and sixth days of life in a series of 181 infants has failed to provide evidence to suggest that previous maternal oral contraception, maternal oxytocin infusion, epidural anaesthesia, or breast-feeding are factors influencing neonatal jaundice.
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PMID:Influence of previous oral contraception and maternal oxytocin infusion on neonatal jaundice. 484 30

1. The neurones of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) were stimulated electrically in lactating cats under chloralose anaesthesia. Milk-ejection responses were used to monitor the release of oxytocin and vasopressin and both hormones were assayed in samples of blood collected during stimulation. The position of the tip of the stimulating electrode was confirmed from brain sections stained selectively for cystine-rich neurosecretory material.2. A previous finding that stimulation of the SON in the cat releases vasopressin without oxytocin was confirmed.3. Stimulation of the PVN caused both hormones to be released. The ratio of their concentrations in blood was variable; this suggests release from separate neurones.4. Both hormones were also released on stimulation of the median eminence but not of the zone lying vertically between this structure and the PVN. No neurosecretory material was detected in this zone. These findings argue against the existence of a direct or medial paraventriculo-hypophysial pathway running downwards along the wall of the third ventricle.5. Study of sections from unstimulated brains confirmed that the tractus paraventricularis cinereus of Greving which runs ventro-laterally from the PVN towards the SON, represents the principal efferent pathway for neurosecretory fibres from the PVN.6. The results are discussed in relation to the problem of the independent release of oxytocin and vasopressin in response to physiological stimulation of the neurohypophysis.
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PMID:The hypothalamic neurosecretory pathways for the release of oxytocin and vasopressin in the cat. 516 44

Studies utilizing glucose-controlled insulin infusion systems were undertaken to more accurately define the glucose and insulin requirements during the first stage of labor induced by oxytocin in 12 insulin-dependent diabetic women in whom normoglycemia had been maintained before delivery. Insulin requirements decreased to zero during active stage 1 labor, while the glucose infusion rate necessary to maintain a blood glucose level of 70 to 90 mg/dl (or 3.9 to 5.0 mmol/liter) was constant at 2.55 mg/kg per minute. The findings were confirmed in 40 additional studies of oxytocin-induced labor. Studies of six women undergoing spontaneous labor and one nonpregnant woman receiving oxytocin confirmed that the decrement in the insulin requirement during stage 1 labor was not influenced by oxytocin infusion. The changes occurred regardless of whether epidural anesthesia was employed. Insulin requirements returned during the second stage of labor. Active stage 1 labor in diabetic women thus appears to be associated with a predictable decrease in the need for insulin and a constant glucose requirement.
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PMID:Insulin and glucose requirements during the first stage of labor in insulin-dependent diabetic women. 635 16

The effect of low-dose prostaglandin E2 vaginal gel specially prepared from commercially available materials, on subsequent indicated oxytocin induction of labor, was investigated in a randomized, double-blind, placebo-controlled clinical trial. The stability of the gel after preparation was documented by radioimmunoassay in vitro. No differences between the treated and placebo groups were noted in subsequent modified Bishop scores, length of labor, use of analgesia or anesthesia, success of induction, mode of delivery, or perinatal outcome. Comparisons of this clinical trial with those previously reported are offered.
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PMID:Variations of biologic activity of low-dose prostaglandin E2 on cervical ripening. 637 45


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