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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypertonic saline administered intraamniotically and followed by oxytocin infusion has been known to cause uterine rupture in a single grandmultiparous patient. A case report is presented on the 1st documented incident of uterine rupture following intraamniotic saline injection followed by oxytocin infusion in a patient of low parity. This uterine rupture occurred prior to expulsion of the fetus or manual removal of the placenta. The patient had experienced already a previous 1st-trimester, vaginal abortion. It is unknown whether this previous abortion had a causative effecton the abnormal placental implantation of this pregnancy, but it is certain that the abnormal implantation probably contributed to the uterine rupture. The adult respiratory distress syndrome which occurred in the case reported is consistent with intraabdominal ahemorrhage and shock. Any hypertonic saline instillation followed by unusual abdominal discomfort, orthostatic hypotension, and anemia should be investigated for the possibility of uterine rupture.
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PMID:Uterine rupture caused by midtrimester saline abortion. 53 74

This study was performed to determine the effect of administration of i.v. oxytocin on the contractility of the musculature associated with the equine oesophagus. Nine clinically normal horses were fitted with a nasogastric tube modified with inflatable latex cuffs. These cuffs were connected to piezoelectric pressure recording devices. Oxytocin in 3 different doses or saline controls were administered i.v. in a randomised block pattern. Systolic blood pressure, ECG, heart rate and nasogastric tube cuff pressures were then measured for 60 min. Administration of oxytocin i.v. at 0.11 and 0.22 iu/kg bwt, resulted in a short-term statistically significant relaxation of the musculature of the equine oesophagus. When oxytocin was administered at 0.11, 0.22 and 0.44 iu/kg bwt, no clinically significant cardiovascular changes were seen. In approximately 5% of the oxytocin administrations, signs of mild short-term abdominal discomfort were observed. In clinical cases of noncomplicated oesophageal obstruction, it is suggested that reduction in tone of oesophageal musculature may result in passage of oesophageal obstructions with reduced risk of oesophageal injury when compared to other traditional treatments.
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PMID:The effect of oxytocin on contractility of the equine oesophagus: a potential treatment for oesophageal obstruction. 1074 71