Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Questionnaires concerning ailments were sent postpartum (mean two years) to 62 women with anal sphincter ruptures (ASR), who were compared with a matched control population. The frequency of anal sphincter rupture at the hospital during delivery in the period, 1978-82, was 0.7% (n = 63). Primiparity, instrumental deliveries, abnormal presentation, large babies and oxytocin stimulation were all risk factors. Of 59 women answering the questionnaire 37 (63%) stated that they had had ailments three months postpartum, mainly with pain and involuntary passage of flatus but also with dyspareunia and occasional incontinence of faeces. Long-term symptoms were noted by 28 (48%) of the women, mainly with involuntary passage of flatus but also perineal pain, dyspareunia and occasional incontinence of faeces. Long-term symptoms occurred in 7 (88%) of women with ASR also involving the anal mucosa, but only in 21 (39%) of those with ASR only. Three of the patients subsequently underwent reconstructive surgery, and three complained of psychological problems.
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PMID:Long-term ailments due to anal sphincter rupture caused by delivery--a hidden problem. 333 6

A double-blind trial was undertaken to assess the effect of oxytocin on the duration of intestinal atony after cholecystectomy. Eleven pairs of patients were either given injections of oxytocin or placebo at regular intervals during the first and second postoperative day. Sequential analysis showed placebo as being more effective, regarding the time until flatus was passed.
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PMID:[Effect of oxytocin on postoperative intestinal atonia after open cholecystectomy]. 829 14