Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intrauterine pressure was measured in 4 reproductively normal mares and 4 mares with delay in uterine clearance after administration of oxytocin to determine if intrauterine pressure varied between dosage and group. Changes in intrauterine pressure were measured during estrus, when a follicle was > or =35 mm, using a Millar "Mikro-tip" catheter that had 3 discrete pressure sensors/channels. Mares received 4 different treatments of 10, 5, 2.5 or 0 IU (vehicle) of oxytocin. The protocol for each treatment consisted of a 10-min baseline recording, administration of treatment and measurement of changes in intrauterine pressure for 65 min. After administration of the first two treatments, mares were rested for 2 h and the protocol repeated for the remaining 2 treatments. Changes in intrauterine pressure were measured on a physiograph and stored in a computer. The results were analyzed by 4x4 Latin Square Design analysis of variance (ANOVA) using the GLM procedure of the Statistical Analysis System. The ANOVA detected a main effect of treatment (P<0.01) and mare (nested within group; P<0.01) but no effect of channels, group or treatment-by-group interaction. There was a dose-dependent increase in uterine activity in both normal mares and those with delayed uterine clearance. A dose of 10 IU of oxytocin induced a larger number of uterine contractions (5.67+/-0.06) for a longer time (24.09+/-1.18 min) than the 5 IU (4.16+/-0.06 contractions and 16.31+/-1.18; P<0.01 min) or 2.5 IU dose (4.08+/-0.06 contractions and 17.61+/-1.18 min). The first intrauterine wave occurred most often near the tip of the horn in 10 of 12 recordings in normal mares and in 8 of 12 recordings in mares with delayed uterine clearance. It was then propagated from the middle of the horn to the uterine body just cranial to the cervix. There was no pattern of propagation for subsequent intrauterine pressure waves. We conclude that the difference in spontaneous clearance of the uterus between the 2 groups is not reflected in their response to exogenous oxytocin as determined by changes in intrauterine pressure.
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PMID:Changes in intrauterine pressure after oxytocin administration in reproductively normal mares and in those with a delay in uterine clearance. 1072 23

Numerous factors, including family planning and modern contraception, disturb the potential associations between the number of children born and genetic factors in modern Western societies. The current progress of medicine and a relatively high level of well-being make it hard to test the association between children's survival rates and genetic factors in Western societies either. The goal of the current study was to reveal the possible associations between the number of children born and the number of children survived till the age of 5 y. by the time of our study with a set of six genetic polymorphisms associated with serotonin, dopamine, androgen oxytocin behavioral effects; and to test for sex-specific effects of these polymorphisms in a traditional rural sample from Arusha and Singida Districts of Northern Tanzania. The data on 965 healthy individuals (520 men and 415 women) from traditional rural communities with high reproduction profiles were collected. All participants provided information on the number of children born and survived, and other demographic information, as well as buccal epithelium samples for DNA analysis. The data were analyzed using GLM ANCOVA and the APSampler nonparametric methodology. The gene association effects on reproduction and infant survival in men and women were demonstrated. We suggest that sex differences revealed in this study are in line with sexual selection pressure on reproduction and parenting in traditional societies.
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PMID:Fertility and infant survival in men and women from rural regions of Northern Tanzania: gene candidates and sex-specific genetic associations. 3329 31