Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinical team in the Dept. of Obstetrics and Gynecology of the Albert Einstein College of Medicine investigated the effects of several prostaglandin compounds of human pregnancy. Women between 8 to 20 weeks gestational age had pregnancy termination through: 1) intraamniotic PGF2alpha (prostaglandin F2a) administration (n=20, 15.9 + or - 0.6 weeks pregnant, 1.4 + or - 0.4 parity); 2) extraovular PGF2a administration (n=20, 13 + or - 0.3 weeks gestation); 3) intramuscular 15-methyl PGF2a administration; 4) vaginal suppositories of PGE2 (n=110 women, 1.45 + or - 0.17 parity, 15.4 + or - 0.3 gestational weeks); and 5) induction of term labor through PGF2a and PGE2 administered orally, intravenously, vaginally, and extraovularly. In the 1st group, the 20 women aborted in 16.5 + or 2.1 hours with an average total dose of 24.3 + or - 1.1 mg. In the 2nd group, the 20 women aborted in 17.9 + or - 2.9 hours with 11 + or - 1.8 mg PGF2a. The 24-hour cumulative abortion rate was 83%. In both intraamniotic and extraovular groups, prostaglandin side effects were noted in 25% to 70% of the women. Incidence of retained placentas was also high. In the 3rd group, abortion did not follow a predictable pattern and side effects occurred in virtually all women, making this approach unacceptable as a therapeutic method. The vaginal suppositories resulted in a mean abortion interval of 14.12 + or 0.7 hours with an average total dose of 78.3 + or - 0.12 mg. Induction of term labor using PGF2a and PGE produced results which are not superior to those of intravenous oxytocin in term pregnancies, possibly because of the biophysical properties of the term uterus. Prostaglandins appear to be effective abortifacient agents with minimal material risk, and are most effective when administered intraamniotically, extraovularly, and paracervically. The chemistry and pharmacology of prostaglandins are briefly described.
 ...
PMID:Prostaglandins in conception control. 108 Feb 45