Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurophysins, vasopressin and oxytocin are not restricted to the hypothalamo-neuropituitary system but are also found in different brain area in relation with cognitive and emotional function and with cardiovascular regulation. During early aging it seems to exist a decrease of the hypothalamic and brain content of vasopressin. It appears that in some patients, presumably suffering from a deficit of central vasopressinergic function, exogenous vasopressin could improve arousal and/or memory. The exact place of this peptide in the treatment of the early aging cognitive deficit remains however to be defined.
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PMID:[Neurophysins, vasopressin and cognitive function in aging]. 666 9

Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition for which effective medications are scant and little is known about neural correlates of risk versus resilience. Oxytocin is a hypothalamic neuropeptide that has demonstrated promise in modulating neurobiological and behavioral correlates of PTSD. Cognitive deficits in areas such as working memory and executive control are highly prevalent among individuals with PTSD and oxytocin might modulate these impairments in individuals with PTSD. Using a double-blind, placebo-controlled design, this study employed functional MRI (fMRI) and the n-back working memory task to examine the effects of oxytocin (24 IU) versus placebo on working memory and dorsolateral prefrontal cortex (DLPFC) connectivity among individuals with PTSD (n = 16) as compared with a trauma-exposed control group (n = 18). Results indicate that individuals with PTSD on oxytocin performed better in the 2-back condition of the n-back task compared with individuals with PTSD on placebo. Results also indicate that connectivity between DLPFC and anterior cingulate increased in the 2-back condition among individuals with PTSD on oxytocin as compared with placebo. These findings provide preliminary evidence of an effect of oxytocin on working memory among individuals with PTSD and insights into the neurobiological mechanisms underlying this association. Future studies are necessary to understand the mechanisms responsible for working memory deficits in PTSD and to examine the potential of oxytocin for use as a treatment for PTSD. (PsycINFO Database Record
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PMID:Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder. 3007 May 67