Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been known for years that prostaglandins can be used to bring on labor. The authors experienced with alpha PGF2 by extraamiotic, intracavitary infusion. The group of 23 patients included 20 cases of incomplete abortion in the second trimester, 9 cases of intrauterine fetal death in the third trimester, and 1 case of vesicular mole. This method proved 82.6% successful: in 56.9% of cases the product of conception was expelled within 12 hours; in 26.5% of cases within 24 hours. Only in 4 cases, 17.4%, this method proved unsuccessful; oxytocin was used in 3 of these 4 cases. Hypertonia was evident immediately after infusion; uterine contractions, measured and registered with a tocograph, were frequent and increasingly intense. Nausea, vomiting and diarrhea were observed in 26.5% of cases; 1 patient had facial flush. These side effects were probably due to the low absorption of the drug into the circulation. Results obtained confirm others described in the literature on the subject.
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PMID:[Induction of labor in missed abortion, fetal death and vesicular mole, using PGF2 alpha by extra-amniotic intracavitary administration]. 60 2