Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension. Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response. OXT-(7-9) was somewhat more potent than OXT and its effect was dose-dependent. Microinjection of OXT-(7-9) into the dorsal raphe nucleus reduced the pressor response as well. [Arg8]vasopressin (AVP) did not affect the pressor response when administered via this route, while prolyl-arginyl-glycinamide (AVP-(7-9] had an action that was similar to that of OXT-(7-9). None of these peptides affected the magnitude of the bradycardiac response. It is suggested that OXT and related fragments modulate neurogenic hypertensive responses through lower brainstem mechanisms.
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PMID:Reduction of a centrally induced pressor response by neurohypophyseal peptides: the involvement of lower brainstem mechanisms. 614 Jan 70

Experiments were done in conscious, unrestrained rats to investigate the effects of selective aortic baroreceptor deafferentation (ABD) on circulating levels of the neurohypophysial hormones arginine vasopressin (AVP) and oxytocin (OXY). Plasma concentration of AVP and OXY were measured by radioimmunoassay before and 1-13 days after cutting the aortic depressor nerves, bilaterally. Arterial pressure was significantly elevated by approximately 12-39 mmHg above control levels after ABD. On day one after ABD, plasma AVP increased from control levels of 3.21 +/- 1.56 pg/ml to 8.29 +/- 4.66 pg/ml (258%) and plasma OXY increased from 2.53 +/- 4.24 pg/ml to 8.16 +/- 1.49 pg/ml (323%). However, by the third day after ABD, plasma AVP and OXY levels had returned to pre-ABD control levels. On days 8 and 13 after ABD, AVP levels were elevated again by approximately 2- and 9-fold, respectively, whereas the OXY levels remained at control levels. These data suggest that in the awake rat, the release of AVP and OXY is modulated differentially after ABD and that the increased circulating levels of AVP may be one of the mechanisms that contributes to the elevated arterial pressure in neurogenic hypertension.
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PMID:Effect of aortic baroreceptor deafferentation on plasma vasopressin and oxytocin in the conscious rat. 895 24