Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of oxytocin (OXT) and vasopressin (VP) on alcohol withdrawal was investigated. CFLP mice were treated with alternating daily injections of tert-butanol and ethanol for four days, which resulted in physical dependence on ethanol. The severity of withdrawal symptoms was assessed by picrotoxin. The lowest dose (0.02 IU) of each of the peptides precipitated tonic convulsions, while higher doses resulted in different tendencies. OXT-treated mice displayed milder withdrawal symptoms in response to increasing doses of peptide (0.2-2.0 IU). VP showed a U-shaped dose-response effect. The lowest (0.02 IU) and the highest (2.0 IU) doses increased the occurrence of withdrawal convulsions and the frequency of deaths.
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PMID:Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. 359 87

The role of central oxytocin in inhibitory action of lithium on the development of morphine dependence was behavioral investigated in rats. Acute lithium could enhance the morphine-induced analgesia in rats with or without chronic morphine treatment; this effect could be inhibited by intraventricular injection of oxytocin antagonist d (CH(2))(5)-Tyr (Me)-[Orn(8)]-Vasotocin (OVT). Lithium could attenuate naloxone-precipitated withdrawal signs in morphine dependent rats. The reduction of the expression of naloxone-precipitated withdrawal signs by lithium was reversed by ICV of OVT. The lithium significantly inhibited the conditioned place preference (CPP) induced by morphine, which inhibitory action of lithium could also reverse by ICV injection of OVT. These results suggested that lithium might inhibit the physical dependence on morphine as well as psychological dependence in rats, and that this inhibitory effect of lithium on the development of morphine dependence might be associated with oxytocin systems in the central nervous system.
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PMID:Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats. 1159 42