Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The use of intraamniotic instillation of hypertonic saline with/without oxytocin in midtrimester abortion can sometimes lead to a fatal complication in the form of intravascular coagulopathy. Intraamniotic urea is used for the same purpose and has a similar mode of action. It decreases the circulating progesterone level and increases prostaglandin release. It can also cause fetal death. One of its major advantages is the lack of significant complications with inadvertent intravenous infusion of urea. 70 cases of midtrimester pregnancies were terminated by injection of 200 ml of urea (40%) intraamniotically between the period 8/77 to 8/78. The patients ranged in age from 20 to 35 years. No relationship was found between the induction-abortion interval and gestation period. Success rate was 88.7%; there were 8 failures. Average induction-abortion interval was 30.7 hours, with maximum abortions occurring between 24-48 hours. There were no major complications. Urea is also used intravenously in sickle cell crisis and neurosurgical procedures.
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PMID:Use of intra-amniotic urea as a second trimester abortifacient. 52 68