Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study is a longitudinal follow-up of 103 women (mean age, 29.7 years) who had hypertonic saline (30%) induction of midtrimester abortion or of labor with fetal death in utero. Mean instillation-abortion time was relatively short, 25.4 hours. Oxytocin was not needed for augmentation of contractions either in elective abortions or missed labor. 90.3% of the women (93) did not exhibit any early complications. Fever and signs of low-grade infection were observed in 8 patients, and hemorrhage in 2. In 71.9% of patients, menses returned within a month after the operation. All patients had a follow-up exam after 2 to 22 years from date of abortion. In 3 women, sequelae possibly related to the saline abortion (hydrosalpinx, incompetent cervix, and intrauterine adhesions) were observed. 69 out of 71 women who desired to become pregnant succeeded. In 94 patients, menses were found to be normal. In 8, bleeding became heavier, and in 1, oligonomenorrhea occurred. The authors concluded that 30% saline induction of midtrimester abortion is simple and effective, and eliminates need for laminaria, oxytocin, additional prostaglandins, and intrauterine or routine oral antibiotics. Reproductive and gynecological complications are minimal.
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PMID:Early complications and sequence of pregnancy interruption with hypertonic saline. 611 32