Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two thousand seven hundred ninety two contraction stress tests (CST) were analysed. Oxytocin was administered in 1730 of these to stimulate uterine contractions and the hyperstimulation which occurred in 48 tests (2.8%) was studied extensively. Seven patients went into labor within 24 hours of the hyperstimulation. Two infants weighed less than 2500 g. One was mature but small-for-dates and the other (who died neonatally) had a trisomy-18 syndrome with severe congenital abnormalities. There were no other intrapartum or neonatal complications. Ten CSTs demonstrated hypertonicity without any preceding oxytocin administration. No harmful effects from the hyperstimulation could be found.
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PMID:Hyperstimulation of the uterus during the oxytocin stress test. 62 47

Prader-Willi syndrome (PWS) is caused by a deficiency of imprinted genes in the 15q11-q13 region and is characterized by prenatal onset of hypotonia, poor feeding, childhood-onset obesity, hyperphagia, short stature, facial dysmorphism, intellectual disability, and behavioral problems. We studied perinatal factors in a cohort of 64 people with PWS resulting from paternal deletion of 15q11-q13 and maternal uniparental disomy (UPD) for chromosome 15. We recruited 34 individuals with deletion and 30 with UPD. We compared the frequency of multiple prenatal and neonatal factors with the general population as well as between the two genetic subtypes. Of the 64 individuals with PWS, fetal movements were decreased in 82.8%, 31.7% were born prematurely, 42.1% by Cesarean section, and 35.9% required oxytocin induction. Apgar scores were low in 34.6%, 96.8% had feeding difficulty, 50% needed tube feeding, and 6.2% subsequently had gastrostomy tube placement. On comparing findings in the deletion versus the UPD groups, we did not find many significant differences. We, however, found a higher maternal age, and also later age at diagnosis in the UPD versus the deletion group. PWS subjects have higher rates of perinatal complications, especially Cesarean section rate, hypotonia, and low Apgar scores compared to the general population. We did not find many differences between the genetic subtypes, except for later age of diagnosis of the UPD 15 group suggesting a milder phenotype. We also found that the mothers in the UPD were older, supporting the hypothesis that UPD results from nondisjunction associated trisomy rescue.
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PMID:Comparison of perinatal factors in deletion versus uniparental disomy in Prader-Willi syndrome. 2968 Nov 3