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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The successful termination of 19 consecutive late 1st and 2nd trimester pregnancies using a combination of intravenous prostaglandin E2 (PGE2) and oxytocin (Syntocinon) is reported. PGE2 (5 mg in 500 ml of 5% glucose) was initially infused at the rate of 2.5 mcg/minute and then increased to 5 mcg/minute after half an hour. The infusion was increased to a maximum of 10 mcg/minute. Oxytocin was infused 2 hours after the PGE2 at a constant rate of 128 mU/minute. Mean total dose of PGE2 used was 5.9 mg at an overall rate of 6.1 mcg/minute. Average induction/delivery interval was 16 hours, with only 1 patient taking more than 24 hours. Abortion was complete in 13 cases (68%). Vomiting occurred in 13 women; pain was minor and was controlled by pethidine. Mild and transient thrombophlebitis was also reported. There were no reported cases of diarrhea and or cervical damage. Compared to the use of intravenous PG alone, PG given intraamniotically alone or with intravenous oxytocin, and PG given extraamniotically alone or with intravenous oxytocin, this study shows that a combination of intravenous PGE2 and oxytocin at the dose level described is closer to meeting all the desired criteria for the acceptability of any abortion method (ease and safety of administration, side effects, lengths of induction delivery interval, and effectiveness in terms of success rate and uterine evacuation).
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PMID:Letter: Intravenous prostaglandins and oxytocin for mid-trimester abortion. 4 97

71 abortions after prenatal diagnosis of genetic defects have been performed between 1974 and 1983. Mean duration of pregnancy was 21 weeks, mean hospital stay 10 days. In 28 per cent an intraamnial prostaglandin induction was done, which was successful in 85 per cent. Extraamnial prostaglandin application was combined with oxytocin in 51 per cent, which was followed by abortion in 51 per cent within 26 hours. Primary hysterectomy was performed in 4 per cent and rupture of the membranes combined with oxytocin infusion in 6 per cent. Complication rate overall was 20 per cent. In 6 per cent the following complications have been observed: 1 perforation with lesion of intestine, 1 cervical rupture with hemorrhage, 1 colpaporrhexis, 1 shock. Pelveoperitonitis and rupture of the symphysis pubis in one case each (3 per cent). Other complications, like fever, hemorrhages and thrombophlebitis have been observed in 11 per cent. Midtrimester abortion after prenatal diagnosis of genetic defects should be done only in experienced clinics. Special importance in prophylaxis of complications of abortion has chorion biopsy to predate prenatal diagnosis in the 6th till 12th gestational week.
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PMID:[Abortion following prenatal diagnosis of genetic defects]. 386 19

Cases of cranial superficial epigastric vein (CSEV) phlebitis with subsequent septicemia were observed in dairy farms in Minas Gerais, Brazil. Autopsy on 4 affected cows, from 2 farms, revealed CSEV thrombophlebitis with perivascular abscesses, pulmonary abscesses, valvular endocarditis, arthritis, thromboembolic nephritis, and renal infarcts. Microscopic examination revealed fibrosing and lymphoplasmacytic phlebitis with occasional endothelial loss, subendothelial areas of necrosis, and abundant fibrin deposition. Trueperella pyogenes, Escherichia coli, and Staphylococcus aureus were isolated from lesions of 3 different cows. Thrombophlebitis of the CSEV is a rare condition in dairy cows; however, it has become more frequent in dairy farms in southeastern Brazil after repeated venipuncture of this vein, likely with contaminated needles used for administration of oxytocin.
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PMID:Cranial superficial epigastric vein phlebitis and septicemia in dairy cows in Brazil. 3102 48