Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypertonic saline administered intraamniotically and followed by oxytocin infusion has been known to cause uterine rupture in a single grandmultiparous patient. A case report is presented on the 1st documented incident of uterine rupture following intraamniotic saline injection followed by oxytocin infusion in a patient of low parity. This uterine rupture occurred prior to expulsion of the fetus or manual removal of the placenta. The patient had experienced already a previous 1st-trimester, vaginal abortion. It is unknown whether this previous abortion had a causative effecton the abnormal placental implantation of this pregnancy, but it is certain that the abnormal implantation probably contributed to the uterine rupture. The adult respiratory distress syndrome which occurred in the case reported is consistent with intraabdominal ahemorrhage and shock. Any hypertonic saline instillation followed by unusual abdominal discomfort, orthostatic hypotension, and anemia should be investigated for the possibility of uterine rupture.
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PMID:Uterine rupture caused by midtrimester saline abortion. 53 74