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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The management of women with spontaneous rupture of membranes at term in the absence of labor and with a cervix unfavorable for induction of labor is controversial. In this randomized study of 182 patients, we report the effects of delayed versus early induction of labor on maternal and neonatal outcome. Qualifying patients not in labor at 6 hours after spontaneous rupture of membranes were randomized to either immediate oxytocin induction (86 women) or expectant management with oxytocin induction at 24 hours if labor had not occurred spontaneously (96 women). The cesarean section rate did not differ between the two groups. Women in the delayed group had significantly longer hospitalization (P less than .003), and their infants were significantly more likely to receive antibiotics (P = .006). Infectious morbidity (positive cultures or x-ray-documented pneumonia) occurred in five of the neonates in the delayed group, all of whose mothers had an initial digital cervical examination, but in none of the neonates in the early group, a difference that did not reach statistical significance (P = .061). Five (28%) of 18 infants from the delayed group whose mothers had received an initial digital cervical examination became infected, compared with none of the 78 infants from the delayed group whose mothers did not have digital examinations (P less than .001). We conclude that there is no advantage to delaying induction of labor when women present at term with spontaneous rupture of membranes.
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PMID:A comparison of early and delayed induction of labor with spontaneous rupture of membranes at term. 273 49

A case of septic induced abortion in a 15-year-old girl referred to the hospital as a pediatric patient with the provisional diagnosis of meningococcemia is reported. The patient was admitted in shock, cyanotic, and vasoconstricted. Pertinent comments by the nurses that the patient admitted coitus 12 to 14 weeks previously and followed by amenorrhea, were apparently ignored. The 1st gynecologic consultant was called after the patient experienced severe cramps and passage of part of a placenta. He recommended intravenous oxytocin and curettage, but this advice was not followed because the hospital pharmacy did not stock oxytocin and because the administration would not permit curettage on a child. Dilation and curettage was performed after transfer to a general hospital. The patient died 6 weeks after admission, and the pathologist's final summary noted that extensive pneumonia together with organizing thrombi suggest that the patient may have thrown septic emboli very early in the course of her disease. It is concluded that errors and omissions were disastrous, but even more reprehensible was the failure of residents to credit nurses' notes or follow consultants' recommendations which clearly pointed all along to the correct diagnosis. Finally, when the patient aborted in bed, the urgency of intervention was not recognized and the time which was her last chance for survival was lost.
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PMID:Septic induced abortion. 472 34

A 26-year-old, gravida 2, para 0 woman with a 12-week pregnancy complicated by incomplete abortion was referred for evacuation of retained products of conception. Suction evacuation was carried out under general anesthesia, but heavy vaginal bleeding continued. Intravenous oxytocin and ergonovine maleate, intramyometrial injection of prostaglandin F2alpha, local pressure to the cervix, uterine massage, and temporary ligation of internal iliac arteries failed to stop the bleeding. The patient received 12 units of blood. The bleeding was finally stopped after inserting a Foley catheter into the cervical canal, inflating its balloon, and applying two cerclage sutures to the cervix above and below the balloon. The woman's postoperative course was complicated by left lung pneumonia, which was treated successfully with antibiotics, and she was discharged home 1 week after admission.
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PMID:Cervical Ectopic Pregnancy 907 19

The aim of the study was to compare a variety of neonatal outcome variables of growth concordant twin gestations (CT) to that of growth discordant twins (DT). Maternal and neonatal charts of live, non-anomalous twins > 25 weeks' gestation from 1984-2000 with no evidence of twin-twin transfusion syndrome were reviewed for several variables. DT occurred in (N = 81) 11.9% of all twin pregnancies. In 61.7% of DT, twin B was the smaller of the twins. There was no difference in maternal age, admission indications, or antepartum complications between both groups. DT had a significantly higher incidence of growth restriction compared to CT (88.9% vs 43.5%, p < 0.001). More mothers of DT required oxytocin (37.0% vs 26.3%, p = 0.024); however, cesarean delivery rate and indications were similar in both groups. A similar percentage of infants had AS < 4 at 1 min and AS < 7 at 5 min in both groups. There was no difference between the 2 groups in neonatal complications including: trauma, respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, pneumonia, seizures, or neonatal mortality. However, DT had a significantly higher incidence of hyperbilirubinemia, need for mechanical ventilation and a longer nursery stay. The neonatal outcome of growth discordant twins is worse than that of concordant twins even in pregnancies uncomplicated by twin-twin transfusion syndrome or congenital anomalies.
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PMID:Neonatal outcome of growth discordant twin gestations. 1295 90

Chorioamnionitis is the inflammatory response to an acute inflammation of the membranes and chorion of the placenta. We provide a critical review of the relationship between chorioamnionitis and the risk of prematurity and adverse maternal-fetal outcome. Chorioamnionitis results as a major risk factor for preterm birth and its incidence is strictly related to gestational age. It is associated with a significant maternal, perinatal and long-term adverse outcomes. The principal neonatal complications are neonatal sepsis, pneumonia, bronchopulmonary dysplasia, perinatal death, cerebral palsy and intraventricular hemorrhage. The role in neonatal outcome is still controversial and more conclusive studies could clarify the relationship between chorioamnionitis and adverse neonatal outcome. Maternal complications include abnormal progression of labour, caesarean section, postpartum hemorrhage, abnormal response after use of oxytocin and placenta abruption. Prompt administration of antibiotics and steroids could improve neonatal outcomes.
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PMID:Chorioamnionitis and prematurity: a critical review. 2295 8