Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01178 (
oxytocin
)
15,767
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oxetanocin-G (OXT-G), a potent antiviral agent, is a novel nucleoside isolated from the culture filtrate of Bacillus megaterium. We investigated the antiviral effect of oral administration of
OXT
-G for five days on woodchuck hepatitis virus (WHV), in vivo, using 12 woodchucks. Woodchucks were randomized into each of four treatment groups according to the dose of
OXT
-G. Two out of six woodchucks treated with 1.0 or 2.0 mg/kg/day of
OXT
-G died. After treatment with
OXT
-G, serum levels of WHV-DNA significantly decreased in all woodchucks. However, the antiviral effect was only partial and levels of serum WHV-DNA returned after the cessation of treatment. The amount of viral replicative intermediates was decreased in livers of woodchucks treated with
OXT
-G. Although further study of the toxicity of this compound would be essential before studies in man can be carried out,
OXT
-G has potent antiviral activity against WHV and may deserve evaluation as an antiviral agent in the treatment of
chronic hepatitis
B infections in humans.
...
PMID:Efficiency of oxetanocin-G, a novel nucleoside against the woodchuck hepatitis virus. 815 78
