Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To determine whether younger teenagers (age 17 years or less) face differing morbidity than other women, a cohort study comparing risks of morbidity at the time of elective abortion between 399 young adolescents aged 17 years or less matched with 399 women aged 20-29 years was undertaken. Only women undergoing suction curettage up to 14 weeks duration of gestation or urea amnioinfusion in combination with intraamniotic prostaglandin F2alpha or intravenous oxytocin at 16-22 weeks duration of gestation were included. Cohert subjects were women who had undergone their abortion care in Fertility Control Center at Johns Hopkins Hospital (Baltimore, Maryland) between January 1, 1976 December 31, 1978. The occurence of endometritis was the only complication found more frequently among the adolescents to a significant degree. Among the endometritis patients, 7 adolescents and 2 control women were hospitalized for intravenous antibiotic therapy. The study indicates that adolescents undergoing abortion procedures are at increased risk for postabortal endometritis once other factors such as gestational age, type of abortion procedure, parity, race, level of operation traning, and socioeconomic status have been controlled. Cervical laceration has been shown previously to be about twice as common among women aged 17 years or less compared with older women. The current study demostrated a similar trend but not to a statistically significant degree. Reasons for the increased rated of postabortal endometritis are unclear. The study demonstrated increased rates of preexisting cervical gonorrhea and urinary tract infection among the adolescents compared with the older women, but all of these women underwent treatment prior to the procedure and none experienced endometritis. Careful monitoring after the procedure for the occurence of infection is of obvious importance. Whether routine use of prophylactic antibiotics in this group would be of substantial benefit may deserve further study.
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PMID:Morbidity risk among young adolescents undergoing elective abortion. 649 41

Physicians reviewed 3355 charts of women who underwent an induced abortion between 1986 and 1990 at the family planning clinic of the Sherbrooke University Hospital in Quebec, Canada, to compare the complication rate of late second trimester abortions (15-20 weeks gestation) with that of first trimester abortions (15 weeks gestation). For all cases, physicians ordered preoperative cervical cultures for gonorrhea and chlamydia and used local anesthesia. They used laminaria tents for cases of at least 13 weeks gestation. They did an ultrasound for all cases of at least 15 weeks gestation. They disinfected the vagina, cervix, and perineum in all cases. They followed the no-touch sterile technique. Cases of at least 15 weeks gestation received iv oxytocin during the operation while the 10-14 week cases received injected oxytocin intracervically. The physicians applied Pratt cervical dilatation, ruptured the membranes, and let the amniotic fluid drain. They use Hern or Bierer forceps with adjunctive suction to empty the conceptus. They scraped the uterine cavity with sharp curettes in all cases to confirm that it was empty. 4.8% of all women had surgical complications which were more likely to occur in the 15-week group than in the or= 15-week group (5.1% vs. 2.9%; p = .056). Most common complications were infection (3.4% vs. 2%; p = .14) and incomplete abortions (0.9% vs. 0.4%, not significant, however). Just 11% of infection cases had to be hospitalized. 4 women experienced uterine perforations (3 in first trimester). Just 2 hospitalization cases were considered major surgical complications: postoperative moderate bleeding for 3 days in an incomplete abortion at 17 weeks, gestation, resulting in transfusion, and a first trimester postoperative infection case with a fever lasting more than 3 days. These findings showed that prudent second trimester dilatation and evacuation is essentially as safe as first trimester suction curettages.
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PMID:A five-year experience with second-trimester induced abortions: no increase in complication rate as compared to the first trimester. 843 43