Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01178 (oxytocin)
 15,767 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 1-yr period, we evaluated prospectively the use of nitroglycerin (NTG) to relieve severe intrapartum fetal distress related to uterine hyperactivity. Sixty to ninety micrograms of NTG were injected intravenously (i.v.) within 2-5 min after onset of severe fetal distress after oxygen administration, left lateral decubitus, and discontinuation of any ongoing oxytocin infusion (62%) had failed to resolve the fetal heart rate abnormality. A second dose (60 or 90 micrograms) was used 2-3 min later as required. NTG was completely effective in 22 cases (fetal distress resolution within 4-5 min with restoration of normal uterine activity) and partially but sufficiently effective in the remaining 2 cases (fetal distress resolution within 4-5 min with residual mild uterine hyperactivity). However, a second dose was required for nine parturients (38%). Six parturients (25%) developed hypotension 2 min after the first NTG injection, with a mean nadir of 93.2 mm Hg (minimum 85 mm Hg). Hypotension was always rapidly reversed with a small single dose of ephedrine (4.5-6 mg). In conclusion, we found small doses (60-180 micrograms) of IV NTG to be associated with resolution of severe fetal distress related to uterine hyperactivity along with negligible side effects.
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PMID:Intravenous nitroglycerin to relieve intrapartum fetal distress related to uterine hyperactivity: a prospective observational study. 914 42

The purpose of this study was to determine which of the two positions used by anesthesiologists to identify the epidural space is more comfortable for pregnant patients. We evaluated both the lateral decubitus position and the sitting position in 90 term parturients who were either not in labor or were in early labor (<or= 4 cm cervical dilation). Exclusion criteria included: (1) oxytocin administration; (2) opioid administration within 12 h; (3) multiple gestation; and (4) previous history of cesarean delivery. Patients were positioned in the left lateral decubitus and sitting positions for 60 s each to achieve maximal flexion of the lumbar spine. Patients were questioned as to which position they felt would be more comfortable during the time necessary to identify the epidural space and place an epidural catheter. Among all patients neither position was clearly superior with regard to patient comfort. However, patients who preferred the left lateral decubitus position weighed less (Wt 78 +/- 2 kg vs 87 +/- 3 kg, P = 0.012) and had lower body mass indices (Wt[kg]/Ht[M]2) (27.4 +/- 0.9 vs 31.3 +/- 1.0, P = 0.006) than patients who preferred the sitting position.
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PMID:Which position is more comfortable for the parturient during identification of the epidural space? 1563 39